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CD247; T-cell surface glycoprotein CD3 zeta chain; T-cell receptor T3 zeta chain (CD3Z, T3Z, TCRZ)
Function:
- probable role in assembly & expression of the TCR complex as well as signal transduction upon antigen triggering
- associates with/activates fyn
- interacts with SLA & SLA2
- interacts with DOCK2 & TRAT1
- interacts with SHB
- phosphorylated on Tyr after T-cell receptor triggering (putative)
Structure:
- belongs to the CD3Z/FCER1G family
- contains 3 ITAM domains
- the ITAM domains mediate interaction with SHB
Compartment: membrane
Alternative splicing: named isoforms=2
Pathology:
- defects in CD247 are a cause of primary T-cell immunodeficiency
- interacts with HIV-1 Nef protein
General
cluster-of-differentiation antigen; cluster designation antigen; CD antigen
oligomerizing protein
phosphoprotein
protein subunit
Properties
SIZE: entity length = 164 aa
MW = 19 kD
COMPARTMENT: cellular membrane
MOTIF: signal sequence {1-21}
transmembrane domain {31-51}
MOTIF: cysteine residue {C32}
MODIFICATION: cysteine residue {C-INTERCHAIN}
Ser phosphorylation site {S58}
ITAM 1 {61-89}
MOTIF: Tyr phosphorylation site {Y64}
Tyr phosphorylation site {Y72}
Tyr phosphorylation site {Y83}
ITAM 2 {100-128}
MOTIF: Tyr phosphorylation site {Y111}
Tyr phosphorylation site {Y123}
ITAM 3 {131-159}
MOTIF: Tyr phosphorylation site {Y142}
Tyr phosphorylation site {Y153}
Database Correlations
OMIM correlations
MORBIDMAP 186780
UniProt P20963
Pfam PF02189
Entrez Gene 919
References
- UniProt :accession P20963
- CD247base; Note: CD247 mutation db
http://bioinf.uta.fi/CD247base/
- Altman A, Coggeshall KM, Mustelin T.
Molecular events mediating T cell activation.
Adv Immunol. 1990;48:227-360. Review. No abstract available.
PMID: 1693465
- Bolen JB, Rowley RB, Spana C, Tsygankov AY.
The Src family of tyrosine protein kinases in hemopoietic
signal transduction.
FASEB J. 1992 Dec;6(15):3403-9. Review.
PMID: 1281458
Component-of
CD3