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T-cell surface glycoprotein CD3 gamma chain; T-cell receptor T3 gamma chain; CD3g (CD3G, T3G)
Function:
- component of the CD3 complex
Structure:
- a di-Leu motif & a Tyr-based motif are individually sufficient to induce both endocytosis & delivery to lysosomes
- contains 1 Ig-like (immunoglobulin-like) domain
- contains 1 ITAM domain
Compartment: membrane
General
glycoprotein
immunoglobulin superfamily protein
phosphoprotein
plasma membrane protein
protein subunit
Properties
SIZE: entity length = 182 aa
MW = 20 kD
COMPARTMENT: cellular membrane
MOTIF: signal sequence {1-22}
immunoglobulin superfamily domain {37-94}
MOTIF: cysteine residue {C46}
MODIFICATION: cysteine residue {C87}
N-glycosylation site {N52}
cysteine residue {C87}
MODIFICATION: cysteine residue {C46}
N-glycosylation site {N92}
transmembrane domain {117-137}
Ser phosphorylation site {S145}
Ser phosphorylation site {S148}
ITAM {149-177}
MOTIF: Di-leucine {153-154}
Tyr phosphorylation site {Y160}
Tyr phosphorylation site {Y171}
Database Correlations
OMIM 186740
MORBIDMAP 186740
UniProt P09693
Pfam PF02189
Entrez Gene 917
Kegg hsa:917
References
- UniProt :accession P09693
- CD3Gbase; Note: CD3G mutation db
http://bioinf.uta.fi/CD3Gbase/
- Wikipedia; Note: CD3 receptor entry
http://en.wikipedia.org/wiki/CD3_receptor
- Altman A, Coggeshall KM, Mustelin T.
Molecular events mediating T cell activation.
Adv Immunol. 1990;48:227-360. Review. No abstract available.
PMID: 1693465
Component-of
CD3