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CD39; ectonucleoside triphosphate diphosphohydrolase 1; NTPDase 1; ecto-ATP diphosphohydrolase; ATPDase; lymphoid cell activation antigen; ecto-apyrase (ENTPD1)
Function:
- inhibitor of platelet activation
- in the nervous system, may hydrolyze ATP & other nucleotides to regulate purinergic neurotransmission
- hydrolyzes ATP & ADP equally well
Cofactor: Ca+2, Mg+2
Structure:
- homodimer, disulfide-linked (putative)
- the N-terminus is blocked
- palmitoylated in the N-terminal part
- belongs to the GDA1/CD39 NTPase family
Compartment: membrane (putative)
Alternative splicing: named isoforms=3
Expression:
- B cells, T cells, NK cells
- endothelial cells
- placenta
Related
CD39 like protein (CD39 like antigen, CD39L, ectonucleoside triphosphate diphosphohydrolase)
General
adenosine triphosphatase (ATPase)
cluster-of-differentiation antigen; cluster designation antigen; CD antigen
glycoprotein
membrane protein
pyrophosphatase (diphosphohydrolase)
Properties
SIZE: entity length = 510 aa
MW = 58 kD
COMPARTMENT: plasma membrane
MOTIF: cytoplasmic domain {1-16}
MOTIF: cysteine residue {C13}
MODIFICATION: palmitate
COMPARTMENT: membrane
transmembrane domain {17-37}
exoplasmic loop {38-478}
MOTIF: Tyr phosphorylation site {Y49}
Tyr phosphorylation site {Y65}
N-glycosylation site {N73}
N-glycosylation site {N227}
N-glycosylation site {N292}
N-glycosylation site {N334}
N-glycosylation site {N371}
N-glycosylation site {N457}
transmembrane domain {479-499}
cytoplasmic domain {500-510}
Database Correlations
OMIM 601752
UniProt P49961
Pfam PF01150
KEGG correlations
ENZYME 3.6.1.5
References
- http://www.pathologyoutlines.com/cdmarkers.html
15 October 2002
- UniProt :accession P49961