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CD38; ADP-ribosyl cyclase 1; cyclic ADP-ribose hydrolase 1; cADPr hydrolase 1; T10
Function:
- synthesizes cyclic ADP-ribose
- also has cADPr hydrolase activity
- ATP inhibits the hydrolase activity
- involved in adhesion between leukocytes & endothelial cells
Structure: belongs to the ADP-ribosyl cyclase family
Compartment: membrane
Alternative splicing: named isoforms=2
Expression: (widely expressed)
- plasma cells (strong immunoreactivity)
- lymphoid progenitor cells
- thymocytes
- NK cells
- B cells
- T cells
- monocytes
- erythroid & myeloid precursors
- brain
- muscle
- kidney
- pancreas
- liver
- testis
- ovary
- placenta
Pathology:
- expressed in:
a) lymphoma
b) neuroblastoma
Notes:
- may be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay
Related
CD38 Ag in tissue
CD38 blasts in specimen
CD38 cells in specimen
lymphoblast
General
cluster-of-differentiation antigen; cluster designation antigen; CD antigen
glycoprotein
hydrolase
membrane protein
Properties
SIZE: entity length = 300 aa
MW = 34 kD
COMPARTMENT: cellular membrane
MOTIF: transmembrane domain {22-42}
cysteine residue {C67}
MODIFICATION: cysteine residue {C82}
cysteine residue {C82}
MODIFICATION: cysteine residue {C67}
cysteine residue {C99}
MODIFICATION: cysteine residue {C180}
N-glycosylation site {N100}
cysteine residue {C119}
cysteine residue {C160}
MODIFICATION: cysteine residue {C173}
N-glycosylation site {N164}
cysteine residue {C173}
MODIFICATION: cysteine residue {C160}
cysteine residue {C180}
MODIFICATION: cysteine residue {C99}
cysteine residue {C201}
N-glycosylation site {N209}
N-glycosylation site {N219}
cysteine residue {C254}
MODIFICATION: cysteine residue {C275}
cysteine residue {C275}
MODIFICATION: cysteine residue {C254}
cysteine residue {C287}
MODIFICATION: cysteine residue {C296}
cysteine residue {C296}
MODIFICATION: cysteine residue {C287}
Database Correlations
OMIM 107270
UniProt P28907
Pfam PF02267
Entrez Gene 952
KEGG correlations
ENZYME 3.2.2.5
References
- http://www.pathologyoutlines.com/cdmarkers.html
15 October 2002
- Entrez Gene :accession 952
- Wikipedia; Note: CD38 entry
http://en.wikipedia.org/wiki/CD38
- UniProt :accession P28907