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CD36; platelet glycoprotein 4; platelet glycoprotein IV; GPIV; glycoprotein IIIb; GPIIIB; leukocyte differentiation antigen CD36; PAS IV; PAS-4; platelet collagen receptor; fatty acid translocase; FAT; Thrombospondin receptor (GP3B, GP4)

Function: - CD36 is an oxidized LDL receptor [3] - specific receptor for oxidized choline glycerophospholipids [6] - seems to have numerous potential physiological functions - binds to collagen, thrombospondin, anionic phospholipids & oxidized LDL - may function as a cell adhesion molecule - directly mediates cytoadherence of Plasmodium falciparum parasitized erythrocytes - binds long chain fatty acids & may function in the transport &/or as a regulator of fatty acid transport Structure: - N-glycosylated & O-glycosylated with a ratio of 2:1 - belongs to the CD36 family Compartment: membrane Expression: - platelets - macrophages - endothelial cells - early erythroid cells - megakaryocytes Pathology: - genetic variation in CD36 influences the severity & outcome of malaria infection - defects in CD36 are the cause of CD36 deficiency - AML M4-M7 (AML M0-M3 usually negatively stained with antibody) - activation of CD36 by choline glycerophospholipids promotes platelet activation, impairs endothelial function & increases foam cell concentration within atherosclerotic plaques [6] Comparative biology: - high CD36 expression required for metastasis in mice [9] - CD36 blocking antibodies inhibited metastases but not development or the primary tumor [9] - CD36 expression on endothelial cells could be key to metastases

Related

scavenger receptor class B member 1 (SRB1, CD36 antigen-like 1, CD36 & LIMP2 analogous 1, CLA-1, collagen type I receptor - thrombospondin receptor-like 1, SCARB1, CD36L1, CLA1, CLA2) scavenger receptor class B member 2 (CD36L2, lysosome membrane protein 2, LIMP2, 85 kDa lysosomal membrane sialoglycoprotein, LGP85)

General

adhesion receptor cluster-of-differentiation antigen; cluster designation antigen; CD antigen glycoprotein phosphoprotein

Properties

SIZE: entity length = 472 aa MW = 53 kD COMPARTMENT: plasma membrane MOTIF: cytoplasmic domain {2-7} MOTIF: cysteine residue {C3} MODIFICATION: palmitate COMPARTMENT: membrane cysteine residue {C7} MODIFICATION: palmitate COMPARTMENT: membrane transmembrane domain {8-29} exoplasmic loop {30-439} MOTIF: N-glycosylation site {N79} N-glycosylation site {N102} N-glycosylation site {N134} N-glycosylation site {N163} N-glycosylation site {N205} N-glycosylation site {N220} N-glycosylation site {N235} cysteine residue {C243} MODIFICATION: cysteine residue {C311} N-glycosylation site {N247} cysteine residue {C272} MODIFICATION: cysteine residue {C333} cysteine residue {C311} MODIFICATION: cysteine residue {C243} cysteine residue {C313} MODIFICATION: cysteine residue {C322} N-glycosylation site {N321} cysteine residue {C322} MODIFICATION: cysteine residue {C313} cysteine residue {C333} MODIFICATION: cysteine residue {C272} N-glycosylation site {N417} transmembrane domain {440-461} cytoplasmic domain {462-472} MOTIF: cysteine residue {C464} MODIFICATION: palmitate COMPARTMENT: membrane cysteine residue {C466} MODIFICATION: palmitate COMPARTMENT: membrane

Database Correlations

OMIM correlations MORBIDMAP 173510 UniProt P16671 Pfam PF01130 Entrez Gene 948 Kegg hsa:948

References

  1. Fackler MJ, Civin CI, Sutherland DR, Baker MA, May WS. Activated protein kinase C directly phosphorylates the CD34 antigen on hematopoietic cells. J Biol Chem. 1990 Jul 5;265(19):11056-61. PMID: 1694174
  2. Bolen JB, Rowley RB, Spana C, Tsygankov AY. The Src family of tyrosine protein kinases in hemopoietic signal transduction. FASEB J. 1992 Dec;6(15):3403-9. Review. PMID: 1281458
  3. Endemann G, Stanton LW, Madden KS, Bryant CM, White RT, Protter AA. CD36 is a receptor for oxidized low density lipoprotein. J Biol Chem. 1993 Jun 5;268(16):11811-6. PMID: 7685021
  4. http://www.pathologyoutlines.com/cdmarkers.html 15 October 2002
  5. Entrez Gene :accession 948
  6. Podrez EA, Byzova TV, Febbraio M, Salomon RG, Ma Y, Valiyaveettil M, Poliakov E, Sun M, Finton PJ, Curtis BR, Chen J, Zhang R, Silverstein RL, Hazen SL. Platelet CD36 links hyperlipidemia, oxidant stress and a prothrombotic phenotype. Nat Med. 2007 Sep;13(9):1086-95. Epub 2007 Aug 26. PMID: 17721545 - Jackson SP, Calkin AC. The clot thickens-oxidized lipids and thrombosis. Nat Med. 2007 Sep;13(9):1015-6. PMID: 17828215
  7. Wikipedia CD36 entry http://en.wikipedia.org/wiki/CD36
  8. GeneReviews https://www.genecards.org/cgi-bin/carddisp.pl?gene=CD36
  9. Ledford H Fat fuels cancer's spread in mice Dietary needs of these wandering cells could prove to be their Achilles heel. Nature News. December 7, 2016 http://www.nature.com/news/fat-fuels-cancer-s-spread-in-mice-1.21092 - Pascual G, Avgustinova A, Mejetta S et al Targeting metastasis-initiating cells through the fatty acid receptor CD36. Nature. December 2016 PMID: 27974793