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CD31; platelet endothelial cell adhesion molecule; PECAM-1; endoCAM; GPIIA (PECAM1)

Function: - implicated in angiogenesis, transendothelial leukocyte migration & integrin activation - cell adhesion molecule expressed on platelets & at endothelial cell intercellular junctions - phosphorylated on Ser & Tyr after cellular activation Structure: contains 6 Ig-like C2-type domain (immunoglobulin-like) Compartment: membrane Alternative splicing: named isoforms=6 Expression: - long isoform predominates all tissues examined - isoform delta12 was detected only in trachea - isoform delta14-15 only in lung - isoform delta14 was detected in all tissues examined with strongest expression in heart - endothelium - platelets - macrophages - granulocytes - T cells/NK cells Pathology: - expressed in: a) epithelioid hemangioendothelioma b) vascular tumors c) histiocytic malignancies d) carcinomas & other sarcomas - rare

Related

CD31 Ag in tissue endothelial cell granulocyte lymphocyte monocyte platelet

General

adhesion receptor cluster-of-differentiation antigen; cluster designation antigen; CD antigen glycoprotein immunoglobulin superfamily protein

Properties

SIZE: entity length = 738 aa MW = 83 kD COMPARTMENT: cellular membrane MOTIF: signal sequence {1-27} immunoglobulin superfamily domain {35-121} MOTIF: N-glycosylation site {N52} cysteine residue {C57} MODIFICATION: cysteine residue {C109} N-glycosylation site {N84} cysteine residue {C109} MODIFICATION: cysteine residue {C57} immunoglobulin superfamily domain {145-233} MOTIF: N-glycosylation site {N151} cysteine residue {C152} MODIFICATION: cysteine residue {C206} cysteine residue {C206} MODIFICATION: cysteine residue {C152} immunoglobulin superfamily domain {236-315} MOTIF: cysteine residue {C256} MODIFICATION: cysteine residue {C304} Tyr phosphorylation site {Y290} N-glycosylation site {N301} cysteine residue {C304} MODIFICATION: cysteine residue {C256} N-glycosylation site {N320} immunoglobulin superfamily domain {328-401} MOTIF: N-glycosylation site {N344} cysteine residue {C347} MODIFICATION: cysteine residue {C386} N-glycosylation site {N356} cysteine residue {C386} MODIFICATION: cysteine residue {C347} immunoglobulin superfamily domain {424-493} MOTIF: cysteine residue {C431} MODIFICATION: cysteine residue {C476} N-glycosylation site {N453} cysteine residue {C476} MODIFICATION: cysteine residue {C431} immunoglobulin superfamily domain {499-591} MOTIF: cysteine residue {C523} MODIFICATION: cysteine residue {C572} N-glycosylation site {N551} cysteine residue {C572} MODIFICATION: cysteine residue {C523} transmembrane domain {602-620} Tyr phosphorylation site {Y713} MISC-INFO: DISTRIBUTION :RANGE WIDE

References

  1. Stockinger et al J Immunol 145:3889 1990
  2. http://www.pathologyoutlines.com/cdmarkers.html 15 October 2002
  3. SHMPD; The Singapore human mutation and polymorphism database http://shmpd.bii.a-star.edu.sg/gene.php?genestart=A&genename=PECAM-1
  4. Wikipedia; Note: CD31 entry http://en.wikipedia.org/wiki/CD31
  5. Functional glycomics gateway - glycan binding; PECAM-1 http://www.functionalglycomics.org/glycomics/GBPServlet?&operationtype=view&cbpId=cbp_hum_Itlect_265
  6. UniProt :accession P16284

Databases & Figures

OMIM 173445 UniProt P16284 Pfam PF00047 Kegg hsa:5175 E-cadherin/CD31 ... F-actin