Search
CD2-associated protein (Cas ligand with multiple SH3 domains, adapter protein CMS, CD2AP)
Function:
1) adapter protein between membrane proteins & actin cytoskeleton
2) role in receptor clustering & cytoskeletal polarity in junction between T-cell & antigen-presenting cell
3) may anchor podocyte slit diaphragm to the actin cytoskeleton in renal glomerulus
4) interacts through its second SH3 domain with phosphorylated CBL C-terminus
5) interacts with BCAR1/p130Cas SH3 domain
6) interacts with F-actin, CD2, PKD2, NPHS1 & NPHS2
7) interacts with FAM125A
8) phosphorylated on tyrosine residues, probably by c-Abl, Fyn & c-Src
Structure:
- homodimer, mediated by coiled coil domain
- contains 3 SH3 domains
- Pro-rich domain may mediate binding to SH3 domains
Compartment:
- cytoplasm
- colocalizes with F-actin & BCAR1/p130Cas in membrane ruffles
- located at podocyte slit diaphragm between podocyte foot processes
Expression: widely expressed in fetal and adult tissues
Pathology:
- defects in CD2AP are the cause of susceptibility to focal segmental glomerulosclerosis 3
General
cytoskeletal protein
phosphoprotein
Properties
SIZE: MW = 71 kD
entity length = 639 aa
COMPARTMENT: cytoplasm
MOTIF: src homology 3 [SH3] domain
SITE: 1-59
Tyr phosphorylation site {Y88}
src homology 3 [SH3] domain
SITE: 108-167
src homology 3 [SH3] domain
SITE: 269-330
proline-rich region
SITE: 336-422
MOTIF: proline residue (SEVERAL)
SH3-binding site
NAME: SH3-binding site
SITE: 336-352
SH3-binding site
NAME: SH3-binding site
SITE: 378-397
SH3-binding site
NAME: SH3-binding site
SITE: 410-422
coiled coil {577-638}
Database Correlations
OMIM correlations
UniProt Q9Y5K6
Pfam PF00018
References
- UniProt :accession Q9Y5K6
- GeneReviews
https://www.genecards.org/cgi-bin/carddisp.pl?gene=CD2AP