CD278; inducible T-cell co-stimulator (ICOS); activation-inducible lymphocyte immunomediatory molecule (AILIM)

Function: - enhances T cell responses to foreign antigen - interacts with receptor for ICOS ligand Compartment: membrane & secreted forms Expression: - activated T cells - tonsillar T cells - lower levels in - thymus, lymph node, lung, peripheral blood leukocytes Pathology: - mutations associated with ICOS deficiency, a form of common variable immunodeficiency

General

cluster-of-differentiation antigen; cluster designation antigen; CD antigen glycoprotein

Properties

COMPARTMENT: plasma membrane MOTIF: glycosylation site membrane region

Database Correlations

OMIM correlations UniProt Q9Y6W8 Entrez Gene 29851

References

Uniprot :accession Q9Y6W8