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CD272; B- & T-lymphocyte attenuator; B- & T-lymphocyte-associated protein (BTLA)
Function:
- lymphocyte inhibitory receptor
- inhibits lymphocytes during immune response
- interacts with PTPN6/SHP-1, PTPN11/SHP-2, TNFRSF14/HVEM
- phosphorylated by TNFRSF14
Structure:
- N-glycosylated
- contains 1 Ig-like V-type domain
Compartment:
- single-pass type 1 membrane protein (putative)
Alternative splicing: named isoforms=2
General
cluster-of-differentiation antigen; cluster designation antigen; CD antigen
glycoprotein
phosphoprotein
receptor
Properties
SIZE: MW = 33 kD
entity length = 289 aa
COMPARTMENT: cellular membrane
MOTIF: signal sequence {1-30}
cysteine residue {C34}
MODIFICATION: cysteine residue {C63}
immunoglobulin superfamily domain {43-134}
MOTIF: cysteine residue {C58}
MODIFICATION: cysteine residue {C115}
cysteine residue {C63}
MODIFICATION: cysteine residue {C34}
N-glycosylation site {N75}
N-glycosylation site {N94}
N-glycosylation site {N110}
cysteine residue {C115}
MODIFICATION: cysteine residue {C58}
transmembrane domain {158-178}
Database Correlations
OMIM 607925
UniProt Q7Z6A9
Entrez Gene 151888
Kegg hsa:151888
References
UniProt :accession Q7Z6A9