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CD27, CD27L receptor, TNF receptor family, member 7 (TNFRSF7) or T-cell activation antigen T4
Function:
- receptor for CD70
- may play role in differentiation & survival of activated T cells, also B cell proliferation
- interacts with SIVA1 & TRAF2
Structure:
- homodimer.
- contains 3 TNFR-Cys repeats
Compartment: membrane
Expression:
- T cells, memory B cells
Laboratory:
- marker for T cell activation
Related
CD27 Ag in tissue
CD27 soluble in body fluid
CD70 antigen; CD27 ligand; CD27-L; tumor necrosis factor ligand superfamily member 7 (CD70, CD27L, CD27LG, TNFSF7)
General
cluster-of-differentiation antigen; cluster designation antigen; CD antigen
glycoprotein
phosphoprotein
tumor necrosis factor [TNF] receptor family
Properties
SIZE: MW = 29 kD
entity length = 260 aa
COMPARTMENT: plasma membrane
MOTIF: TNFR/NGFR cysteine rich region {26-63}
TNFR/NGFR cysteine rich region {64-104}
MOTIF: N-glycosylation site {N95}
TNFR/NGFR cysteine rich region {105-141}
transmembrane domain {192-212}
Ser phosphorylation site {S219}
Database Correlations
OMIM 186711
UniProt P26842
Pfam PF00020
Entrez Gene 939
Kegg hsa:939
References
- Taga T & Kishimoto T
Cytokine receptors and signal transduction.
FASEB J 6:3387 1992
PMID: 1334470
- UniProt :accession P26842
- http://www.pathologyoutlines.com/cdmarkers.html
15 October 2002
- Entrez Gene :accession 939