CD244, natural killer cell receptor 2B4 (NKR2B4), NK cell type I receptor protein 2B4 (h2B4) or NK cell activation-inducing ligand (NAIL)

Function: - may modulate other receptor-ligand interactions to enhance leukocyte activation - interacts with CD48 - after phosphorylation, recruits a) PTPN11/SHP-2 b) SH2D1A/SAP - binding of SH2D1A/SAP to CD244 prevents its association with PTPN11/SHP-2 Structure: contains 2 Ig-like (immunoglobulin-like) domains Compartment: membrane Alternative splicing: named isoforms=4 Expression: - expressed in NK cells, monocytes, basophils, spleen, lung liver, testis, small intestine

General

cluster-of-differentiation antigen; cluster designation antigen; CD antigen cell surface receptor glycoprotein phosphoprotein

Properties

SIZE: entity length = 370 aa MW = 42 kD COMPARTMENT: cellular membrane MOTIF: signal sequence {1-21} immunoglobulin superfamily domain {25-126} MOTIF: N-glycosylation site {N71} N-glycosylation site {N77} N-glycosylation site {N89} immunoglobulin superfamily domain {131-215} MOTIF: cysteine residue {C157} MODIFICATION: cysteine residue {C199} N-glycosylation site {N164} N-glycosylation site {N181} N-glycosylation site {N192} cysteine residue {C199} MODIFICATION: cysteine residue {C157} N-glycosylation site {N200} N-glycosylation site {N213} transmembrane domain {230-250} Tyr phosphorylation site {Y271} Tyr phosphorylation site {Y369}

Database Correlations

OMIM 605554 MORBIDMAP 605554 UniProt Q9BZW8 Entrez Gene 51744 Kegg hsa:5174

References

Uniprot Q9BZW8