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CD226; DNAX accessory molecule 1; platelet & T cell activation antigen 1 (PTA1, DNAM1)
Function:
- mediates intercellular adhesion
- lymphocyte signaling
- cytotoxicity
- lymphokine secretion mediated by cytotoxic T lymphocytes
- phosphorylated
- interacts with PVR & PVRL2
Structure:
- contains 2 Ig-like C2-type domain (immunoglobulin-like)
Compartment:
- membrane; single-pass type 1 membrane protein (putative)
Expression:
- NK cells
- platelets
- monocytes
- subset of B-cells & T-cells
- negative antibody staining:
a) granulocytes
b) erythrocytes
General
cluster-of-differentiation antigen; cluster designation antigen; CD antigen
glycoprotein
phosphoprotein
receptor
Properties
SIZE: entity length = 336 aa
MW = 39 kD
COMPARTMENT: cellular membrane
MOTIF: signal sequence {1-18}
immunoglobulin superfamily domain {19-126}
MOTIF: N-glycosylation site {N32}
cysteine residue {C37}
MODIFICATION: cysteine residue {C108}
N-glycosylation site {N83}
N-glycosylation site {N90}
N-glycosylation site {N97}
cysteine residue {C108}
MODIFICATION: cysteine residue {C37}
immunoglobulin superfamily domain {135-239}
MOTIF: N-glycosylation site {N147}
cysteine residue {C152}
MODIFICATION: cysteine residue {C222}
N-glycosylation site {N186}
N-glycosylation site {N198}
cysteine residue {C222}
MODIFICATION: cysteine residue {C152}
N-glycosylation site {N231}
transmembrane domain {255-275}
arginine-rich region {277-284}
MOTIF: arginine residue (SEVERAL)
Ser phosphorylation site {S290}
Tyr phosphorylation site {Y322}
Database Correlations
OMIM 605397
UniProt Q15762
Pfam PF07686
Entrez Gene 10666
Kegg hsa:10666
References
- Uniprot :accession Q15762
- http://www.pathologyoutlines.com/cdmarkers.html
21 June 2005