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CD201; endothelial protein C receptor; activated protein C receptor; APC receptor (PROCR)
Function:
- binds activated protein C
- role in protein C pathway control of blood coagulation
- enhances protein C activation by thrombin-thrombomodulin complex
- binds protein C (Ca+2 dependent)
Structure:
- N-glycosylated
Compartment:
- soluble & membrane forms
- soluble form probably released by a metalloprotease
- seems to have the same activity as the membrane-bound form
Expression:
- expressed in endothelial cells
a) arteries & veins in heart & lung (strong expression)
b) capillaries in the lung & skin (less strong)
- not expressed in small vessels of liver & kidney
Pathology:
- mutations associated with
a) venous thromboembolism
b) myocardial infarction
c) late fetal loss during pregnancy
General
cluster-of-differentiation antigen; cluster designation antigen; CD antigen
glycoprotein
receptor
Properties
SIZE: entity length = 238 aa
MW = 27 kD
COMPARTMENT: cellular membrane
MOTIF: signal sequence {1-17}
N-glycosylation site {N47}
N-glycosylation site {N64}
cysteine residue {C118}
MODIFICATION: cysteine residue {C186}
N-glycosylation site {N136}
N-glycosylation site {N172}
cysteine residue {C186}
MODIFICATION: cysteine residue {C118}
transmembrane domain {211-231}
Database Correlations
OMIM 600646
UniProt Q9UNN8
Entrez Gene 10544
Kegg hsa:1054
References
- Uniprot Q9UNN8
- http://www.pathologyoutlines.com/cdmarkers.html
21 June 2005
- Entrez Gene 10544
- SeattleSNPs
http://pga.gs.washington.edu/data/procr/