CD180 antigen; lymphocyte antigen 64; Radioprotective 105 kD protein; (CD180, LY64, RP105)

Function: - may cooperate with MD-1 & TLR4 to mediate the innate immune response to bacterial lipopolysaccharide (LPS) in B-cells - leads to NF-kappa-B activation - also involved in the life/death decision of B-cells (putative) - binds to MD-1 Structure: - belongs to the Toll-like receptor family - contains 17 LRR repeats (leucine-rich repeats) Compartment: cell membrane Expression: - expressed mainly on mature peripherical B cells - detected in spleen, lymph node & appendix - not detected in pre-B cells & -T cells Pathology: - decreased expression of LY64 has been shown in - systemic lupus erythematosus (SLE) - loss of LY64 is associated with B-cell activation & increased disease activity in SLE patients

General

cluster-of-differentiation antigen; cluster designation antigen; CD antigen cell surface receptor glycoprotein leucine-rich repeat-containing protein (LRRC)

Properties

SIZE: entity length = 661 aa MW = 74 kD COMPARTMENT: cellular membrane MOTIF: signal sequence {1-23} N-glycosylation site {N34} leucine-rich repeat SITE: 51-75 MOTIF: leucine residue (SEVERAL) N-glycosylation site {N53} N-glycosylation site {N70} leucine-rich repeat SITE: 76-99 MOTIF: leucine residue (SEVERAL) N-glycosylation site {N78} leucine-rich repeat SITE: 101-123 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 148-172 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 174-195 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 198-221 MOTIF: leucine residue (SEVERAL) N-glycosylation site {N201} N-glycosylation site {N234} N-glycosylation site {N244} leucine-rich repeat SITE: 273-296 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 297-320 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 323-346 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 353-369 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 370-392 MOTIF: leucine residue (SEVERAL) N-glycosylation site {N394} leucine-rich repeat SITE: 395-418 MOTIF: leucine residue (SEVERAL) N-glycosylation site {N402} leucine-rich repeat SITE: 420-443 MOTIF: leucine residue (SEVERAL) N-glycosylation site {N451} leucine-rich repeat SITE: 468-494 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 496-518 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 519-540 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 541-565 MOTIF: leucine residue (SEVERAL) N-glycosylation site {N573} transmembrane domain {627-650}

Database Correlations

OMIM 602226 UniProt Q99467 PFAM correlations Entrez Gene 4064 Kegg hsa:4064

References

UniProt :accession Q99467