hyaluronan mediated motility receptor; intracellular hyaluronic acid-binding protein; receptor for hyaluronan-mediated motility; CD168 (HMMR, IHABP, RHAMM)

Function: - role in cell motility - hyaluronan binding results in phosphorylation of a number of proteins, including the focal adhesion kinase - may also be involved in regulating extracellular-regulated kinase (ERK) activity - subunit of the HARC complex Compartment: cell surface, cytoplasm (putative) Alternative splicing: named isoforms=2 Expression: - expressed in breast cancer cell lines & in normal breast tissue Pathology: - may be involved in cellular transformation & metastasis

General

cluster-of-differentiation antigen; cluster designation antigen; CD antigen cell surface receptor glycoprotein phosphoprotein

Properties

SIZE: entity length = 724 aa MW = 84 kD COMPARTMENT: cytoplasm MOTIF: Ser phosphorylation site {S20} N-glycosylation site {N133} N-glycosylation site {N477} N-glycosylation site {N567} N-glycosylation site {N588} binding site SITE: 635-645 FOR-BINDING-OF: HYALURONIC ACID binding site SITE: 657-666 FOR-BINDING-OF: HYALURONIC ACID Thr phosphorylation site {T703}

Database Correlations

OMIM 600936 UniProt O75330 Kegg hsa:3161

References

UniProt :accession O75330