CD166 antigen; activated leukocyte cell adhesion molecule; CD166 (ALCAM, MEMD)

Function: - cell adhesion molecule that binds to CD6 - role in neurite extension by neurons via heterophilic & homophilic interactions - may play a role in the binding of T- & B-cells to activated leukocytes, as well as in interactions between cells of the nervous system Structure: - CD6 binding site in the N-terminal Ig-like domain - contains 3 Ig-like C2-type domain (immunoglobulin-like) - contains 2 Ig-like V-type domain (immunoglobulin-like) Compartment: - membrane; single-pass type 1 membrane protein Alternative splicing: named isoforms=2 Expression: - expressed in spleen, placenta, liver, & weakly in liver - expressed by activated T-cells, B-cells, monocytes & thymic epithelial cells - expressed by neurons in the brain - restricted expression in tumor cell lines - preferentially expressed in highly metastasizing melanoma cell lines

General

cluster-of-differentiation antigen; cluster designation antigen; CD antigen glycoprotein immunoglobulin superfamily protein membrane protein

Properties

SIZE: entity length = 583 aa MW = 65 kD COMPARTMENT: cellular membrane MOTIF: signal sequence {1-27} immunoglobulin superfamily domain {28-120} MOTIF: cysteine residue {C43} MODIFICATION: cysteine residue {C113} N-glycosylation site {N91} N-glycosylation site {N95} cysteine residue {C113} MODIFICATION: cysteine residue {C43} immunoglobulin superfamily domain {125-234} MOTIF: cysteine residue {C157} MODIFICATION: cysteine residue {C220} N-glycosylation site {N167} cysteine residue {C220} MODIFICATION: cysteine residue {C157} immunoglobulin superfamily domain {245-328} MOTIF: N-glycosylation site {N265} cysteine residue {C270} MODIFICATION: cysteine residue {C313} N-glycosylation site {N306} cysteine residue {C313} MODIFICATION: cysteine residue {C270} immunoglobulin superfamily domain {333-409} MOTIF: cysteine residue {C354} MODIFICATION: cysteine residue {C392} N-glycosylation site {N361} cysteine residue {C392} MODIFICATION: cysteine residue {C354} immunoglobulin superfamily domain {416-501} MOTIF: cysteine residue {C435} MODIFICATION: cysteine residue {C485} N-glycosylation site {N457} N-glycosylation site {N466} N-glycosylation site {N480} cysteine residue {C485} MODIFICATION: cysteine residue {C435} N-glycosylation site {N499} transmembrane domain {528-549}

Database Correlations

OMIM 601662 UniProt Q13740 PFAM correlations Entrez Gene 214 Kegg hsa:214

References

UniProt :accession Q13740