CD164; sialomucin core protein 24; MUC-24; endolyn; multi-glycosylated core protein 24; MGC-24; MGC-24v (CD164)

Function: - sialomucin that may play a key role in hematopoiesis by facilitating adhesion of CD34(+) cells to the stroma & by negatively regulating CD34(+)CD38(lo/-) cell proliferation - modulates migration of umbilical cord blood CD133+ cells via CXCL12/CXCR4 - promotes myogenesis by enhancing CXCR4-dependent cell motility - positively regulates myoblast migration & promotes myoblast fusion into myotubes - interacts with CXCR4 - role in regulating ErbB2 signaling Structure: - highly N-glycosylated & O-glycosylated - contains sialic acid - the motif Ser-Gly may serve as the site of attachment of a glycosaminoglycan side chain - homodimer (isoform 4) - belongs to the CD164 family Compartment: - single-pass type 1 membrane protein - lysosome membrane, endosome membrane, plasma membrane - isoform 2: secreted (putative) Alternative splicing: named isoforms=5 Expression: - isoform 1 & isoform 3 are expressed in hematopoietic & non-hematopoietic tissues - isoform 2 is expressed in the small intestine, colon, lung, & thyroid & in colorectal adenocarcinoma & pancreatic adenocarcinoma - isoform 4 is expressed by both hematopoietic progenitor cells & bone marrow stromal cells - up-regulated by CXCL12 in prostate cancer cell lines Pathology: - may play a role in prostate cancer metastasis & the infiltration of bone marrow by cancer cells - isoform 1 is expressed by prostate cancer tumors & prostate cancer cell lines - expression is greater in bone metastases than in primary tumors - expression in osseous metastasis is greater than that in soft tissue metastasis

General

cluster-of-differentiation antigen; cluster designation antigen; CD antigen mucoprotein secreted protein

Properties

SIZE: entity length = 197 aa MW = 21 kD COMPARTMENT: lysosome cellular membrane MOTIF: signal sequence {1-23} N-glycosylation site {N26} N-glycosylation site {N32} N-glycosylation site {N41} N-glycosylation site {N72} N-glycosylation site {N77} N-glycosylation site {N94} N-glycosylation site {N104} threonine-rich region {105-152} MOTIF: threonine residue (SEVERAL) N-glycosylation site {N121} Ser glycosylation site {S142} N-glycosylation site {N146} transmembrane domain {163-183} endosomal/lysosomal localization {191-197}

Database Correlations

OMIM 603356 UniProt Q04900 Pfam PF05283 Entrez Gene 8763 Kegg hsa:8763

References

UniProt :accession Q04900