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killer cell immunoglobulin-like receptor 3DL2; MHC class I NK cell receptor; natural killer-associated transcript 4; NKAT-4; p70 natural killer cell receptor clone CL-5; CD158 antigen-like family member K; CD158k (KIR3DL2, CD158K, NKAT4)
Function:
- receptor on natural killer (NK) cells for HLA-A alleles
- inhibits the activity of NK cells thus preventing cell lysis
Structure:
- belongs to the immunoglobulin superfamily
- contains 3 Ig-like C2-type domain (immunoglobulin-like)
Compartment: cell membrane
General
CD158
glycoprotein
killer cell immunoglobulin like receptor 3DL (KIR3DL)
Properties
SIZE: entity length = 455 aa
MW = 50 kD
COMPARTMENT: cellular membrane
MOTIF: signal sequence {1-21}
immunoglobulin superfamily domain {42-102}
MOTIF: cysteine residue {C49}
MODIFICATION: cysteine residue {C95}
cysteine residue {C95}
MODIFICATION: cysteine residue {C49}
immunoglobulin superfamily domain {137-202}
MOTIF: cysteine residue {C144}
MODIFICATION: cysteine residue {C195}
N-glycosylation site {N179}
cysteine residue {C195}
MODIFICATION: cysteine residue {C144}
immunoglobulin superfamily domain {237-300}
MOTIF: N-glycosylation site {N239}
cysteine residue {C244}
MODIFICATION: cysteine residue {C293}
N-glycosylation site {N273}
cysteine residue {C293}
MODIFICATION: cysteine residue {C244}
N-glycosylation site {N306}
transmembrane domain {341-360}
Database Correlations
OMIM 604947
UniProt P43630
Pfam PF00047
Entrez Gene 3812
Kegg hsa:3812
References
- UniProt :accession P43630
- http://mpr.nci.nih.gov/prow/guide/2093594872_g.htm
- Entrez Gene :accession 3812