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killer cell immunoglobulin-like receptor 2DL3; MHC class I NK cell receptor; natural killer-associated transcript 2; NKAT-2; NKAT2a; NKAT2b; p58 natural killer cell receptor clone CL-6; p58 NK receptor; p58.2 MHC class-I-specific NK receptor; killer inhibitory receptor cl 2-3; KIR-023GB; CD158 antigen-like family member B2; CD158b2 (KIR2DL3, CD158B2, KIRCL23, NKAT2)
Function:
- receptor on natural killer (NK) cells for HLA-C alleles (HLA-Cw1, HLA-Cw3 & HLA-Cw7)
- inhibits the activity of NK cells thus preventing cell lysis
Structure:
- belongs to the immunoglobulin superfamily
- contains 2 Ig-like C2-type domain (immunoglobulin-like)
Compartment: cell membrane
Alternative splicing: named isoforms=2
General
CD158
glycoprotein
killer cell immunoglobulin like receptor 2DL (KIR2DL)
Properties
SIZE: entity length = 341 aa
MW = 38 kD
COMPARTMENT: cellular membrane
MOTIF: signal sequence {1-21}
immunoglobulin superfamily domain {42-107}
MOTIF: cysteine residue {C49}
MODIFICATION: cysteine residue {C100}
N-glycosylation site {N84}
cysteine residue {C100}
MODIFICATION: cysteine residue {C49}
immunoglobulin superfamily domain {142-205}
MOTIF: cysteine residue {C149}
MODIFICATION: cysteine residue {C198}
N-glycosylation site {N178}
cysteine residue {C198}
MODIFICATION: cysteine residue {C149}
N-glycosylation site {N211}
transmembrane domain {246-265}
Database Correlations
OMIM 604938
UniProt P43628
Pfam PF00047
Entrez Gene 3804
Kegg hsa:3804
References
- UniProt :accession P43628
- http://mpr.nci.nih.gov/prow/guide/1997822284_g.htm
- Entrez Gene :accession 3804