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killer cell immunoglobulin-like receptor 2DL1; MHC class I NK cell receptor; natural killer-associated transcript 1; NKAT-1; p58 natural killer cell receptor clones CL-42/47.11; p58 NK receptor; p58.1 MHC class-I-specific NK receptor; CD158 antigen-like family member A; CD158a (KIR2DL1, CD158A, NKAT1)
Function:
- receptor on natural killer (NK) cells for HLA-C alleles
- inhibits the activity of NK cells thus preventing cell lysis
Structure:
- belongs to the immunoglobulin superfamily
- contains 2 Ig-like C2-type domain (immunoglobulin-like)
Compartment: cell membrane
General
CD158
glycoprotein
killer cell immunoglobulin like receptor 2DL (KIR2DL)
Properties
SIZE: entity length = 348 aa
MW = 39 kD
COMPARTMENT: cellular membrane
MOTIF: signal sequence {1-21}
immunoglobulin superfamily domain {42-107}
MOTIF: cysteine residue {C49}
MODIFICATION: cysteine residue {C100}
N-glycosylation site {N67}
N-glycosylation site {N84}
cysteine residue {C100}
MODIFICATION: cysteine residue {C49}
immunoglobulin superfamily domain {142-205}
MOTIF: N-glycosylation site {N144}
cysteine residue {C149}
MODIFICATION: cysteine residue {C198}
N-glycosylation site {N178}
cysteine residue {C198}
MODIFICATION: cysteine residue {C149}
transmembrane domain {246-264}
Database Correlations
OMIM 604936
UniProt P43626
Pfam PF00047
References
- UniProt :accession P43626
- http://mpr.nci.nih.gov/prow/guide/531721855_g.htm
- Entrez Gene :accession 3802