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CD151 antigen; platelet-endothelial tetraspan antigen 3; PETA-3; GP27; membrane glycoprotein SFA-1; tetraspanin-24; Tspan-24 (CD151, TSPAN24)
Function:
- essential for the proper assembly of the glomerular & tubular basement membranes in kidney
- interacts with integrins alpha3beta1, alpha5beta1, & alpha6beta4, with CD9 & CD181
Structure:
- belongs to the tetraspanin (TM4SF) family
Compartment: membrane
Expression:
- expressed in a variety of tissues including vascular endothelium & epidermis
- expressed on erythroid cells, with a higher level of expression in erythroid precursors than on mature erythrocytes
- induced by HTLV-1
Polymorphism:
- CD151 defines the MER2=RAPH1 antigen of the RAPH blood group system.
- 92% of Caucasians are MER2-positive & 8% are apparently MER2-negative
Pathology:
- defects in CD151 are the cause of nephropathy with pretibial epidermolysis bullosa & deafness
General
cluster-of-differentiation antigen; cluster designation antigen; CD antigen
glycoprotein
tetraspanin (transmembrane-4-superprotein)
Properties
SIZE: entity length = 253 aa
MW = 28 kD
COMPARTMENT: plasma membrane
MOTIF: cytoplasmic domain {1-18}
MOTIF: cysteine residue {C11}
MODIFICATION: palmitate
COMPARTMENT: membrane
cysteine residue {C15}
MODIFICATION: palmitate
COMPARTMENT: membrane
transmembrane domain {19-39}
exoplasmic loop {40-57}
transmembrane domain {58-78}
cytoplasmic loop {79-91}
transmembrane domain {92-112}
exoplasmic loop {113-221}
MOTIF: N-glycosylation site {N159}
transmembrane domain {222-242}
MOTIF: cysteine residue {C242}
MODIFICATION: palmitate
COMPARTMENT: membrane
cytoplasmic domain {243-253}
MOTIF: cysteine residue {C243}
MODIFICATION: palmitate
COMPARTMENT: membrane
Database Correlations
OMIM correlations
UniProt P48509
Pfam PF00335
Entrez Gene 977
Kegg hsa:977
References
- UniProt :accession P48509
dbRBC/BGMUT; Note: Blood group antigen gene mutation database
http://www.ncbi.nlm.nih.gov/gv/mhc/xslcgi.cgi?cmd=bgmut/systems_info&system=raph
- SeattleSNPs
http://pga.gs.washington.edu/data/cd151/