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CD11b; integrin alpha-M; cell surface glycoprotein MAC-1 subunit alpha; CR-3 alpha chain; leukocyte adhesion receptor MO1; neutrophil adherence receptor; CD11 antigen-like family member B; (ITGAM, CD11B, CR3A)

Function: - subunit of CD11b-CD18 complex (integrin CD11b/CD18) Structure: - the integrin I-domain (insert) is a VWFA domain - integrins with I-domains do not undergo protease cleavage - belongs to the integrin alpha chain family - contains 7 FG-GAP repeats - contains 1 VWFA domain Compartment: membrane Expression: - granulocytes - macrophages, monocytes - predominantly expressed in monocytes & granulocytes - activated microglia - NK cells - follicular dendritic cells - myeloid cells at promyelocyte stage or later Pathology: 1) expressed in: a) AML-M1/AML-M2/AML-M3 ~35-70% b) AML-M4/AML-M5 ~80-90% c) hairy cell leukemia (virtually all) 2) genetic variations in CD11b influence susceptibility to systemic lupus erythematosus [7]

Related

complement C3b granulocyte monocyte natural killer (NK) cell

General

CD11

Properties

SIZE: entity length = 1152 aa MW = 127 kD COMPARTMENT: cellular membrane MOTIF: signal sequence {1-16} FG-GAP {31-84} MOTIF: cysteine residue {C66} MODIFICATION: cysteine residue {C73} cysteine residue {C73} MODIFICATION: cysteine residue {C66} FG-GAP {85-163} MOTIF: N-glycosylation site {N86} cysteine residue {C105} MODIFICATION: cysteine residue {C123} cysteine residue {C123} MODIFICATION: cysteine residue {C105} VWFA domain {164-350} MOTIF: N-glycosylation site {N240} FG-GAP {337-400} MOTIF: N-glycosylation site {N391} FG-GAP {401-452} FG-GAP {454-515} MOTIF: Ca+2-binding site SITE: 465-473 N-glycosylation site {N469} FG-GAP {517-575} MOTIF: Ca+2-binding site SITE: 529-537 FG-GAP {580-632} MOTIF: Ca+2-binding site SITE: 592-600 cysteine residue {C654} MODIFICATION: cysteine residue {C711} N-glycosylation site {N692} N-glycosylation site {N696} cysteine residue {C711} MODIFICATION: cysteine residue {C654} N-glycosylation site {N734} cysteine residue {C770} MODIFICATION: cysteine residue {C776} cysteine residue {C776} MODIFICATION: cysteine residue {C770} N-glycosylation site {N801} cysteine residue {C847} MODIFICATION: cysteine residue {C864} cysteine residue {C864} MODIFICATION: cysteine residue {C847} N-glycosylation site {N880} N-glycosylation site {N900} N-glycosylation site {N911} N-glycosylation site {N940} N-glycosylation site {N946} N-glycosylation site {N978} N-glycosylation site {N993} cysteine residue {C998} MODIFICATION: cysteine residue {C1022} N-glycosylation site {N1021} cysteine residue {C1022} MODIFICATION: cysteine residue {C998} cysteine residue {C1027} MODIFICATION: cysteine residue {C1032} cysteine residue {C1032} MODIFICATION: cysteine residue {C1027} N-glycosylation site {N1044} N-glycosylation site {N1050} N-glycosylation site {N1075} transmembrane domain {1105-1128} GFFKR {1131-1135}

Database Correlations

OMIM correlations UniProt P11215 PFAM correlations Entrez Gene 3684 Kegg hsa:3684

References

  1. Hibbs et al Science 251:1611 1991
  2. Molecular Cell Biology (2nd ed) Darnell J; Lodish H & Baltimore D (eds), Scientific American Books, WH Freeman, NY 1990, pg 921
  3. Cotran et al Robbins Pathologic Basis of Disease, W.B. Saunders Co, Philadelphia, PA 1989 pg 165
  4. Altieri et al J Immunol 1990 Jul 15;145(2):662-70
  5. http://www.pathologyoutlines.com/cdmarkers.html 15 October 2002
  6. Entrez Gene :accession 3684
  7. Hom G, Graham RR, Modrek B et al Association of systemic lupus erythematosus with C8orf13-BLK and ITGAM-ITGAX. N Engl J Med. 2008 Feb 28;358(9):900-9 PMID: 18204098

Component-of

integrin alpha-M/beta-2 (CD11b/CD18, MAC1)