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CD11a; integrin alpha-L; leukocyte adhesion glycoprotein LFA-1 alpha chain; LFA-1A; leukocyte function-associated molecule 1 alpha chain; CD11 antigen-like family member A (ITGAL, CD11A)
Function:
- component of integrin alpha-L/beta-2 (CD11a/CD18)
- forms complex with CD18
- binds to CD54 & CD102
Structure:
- the integrin I-domain (insert) is a VWFA domain.
- integrins with I-domains do not undergo protease cleavage
- belongs to the integrin alpha chain family
- contains 7 FG-GAP repeats
- contains 1 VWFA domain
Compartment: membrane
Alternative splicing: named isoforms=2
Expression:
- all leukocytes
- platelets stain negatively with antibody.
Related
CD11a cells in blood
CD11b cells in bone marrow
General
CD11
Properties
SIZE: entity length = 1170 aa
MW = 129 kD
COMPARTMENT: cellular membrane
MOTIF: signal sequence {1-25}
FG-GAP {42-91}
MOTIF: N-glycosylation site {N65}
cysteine residue {C73}
MODIFICATION: cysteine residue {C80}
cysteine residue {C80}
MODIFICATION: cysteine residue {C73}
N-glycosylation site {N89}
FG-GAP {92-149}
MOTIF: cysteine residue {C111}
MODIFICATION: cysteine residue {C129}
cysteine residue {C129}
MODIFICATION: cysteine residue {C111}
VWFA domain {156-327}
MOTIF: N-glycosylation site {N188}
FG-GAP {350-400}
FG-GAP {401-455}
FG-GAP {457-516}
MOTIF: Ca+2-binding site
SITE: 468-476
FG-GAP {518-575}
MOTIF: Ca+2-binding site
SITE: 530-538
FG-GAP {578-630}
MOTIF: Ca+2-binding site
SITE: 590-598
N-glycosylation site {N649}
cysteine residue {C653}
MODIFICATION: cysteine residue {C707}
N-glycosylation site {N670}
cysteine residue {C707}
MODIFICATION: cysteine residue {C653}
N-glycosylation site {N726}
N-glycosylation site {N730}
cysteine residue {C771}
MODIFICATION: cysteine residue {C777}
cysteine residue {C777}
MODIFICATION: cysteine residue {C771}
cysteine residue {C845}
MODIFICATION: cysteine residue {C861}
cysteine residue {C861}
MODIFICATION: cysteine residue {C845}
N-glycosylation site {N862}
N-glycosylation site {N885}
N-glycosylation site {N897}
cysteine residue {C998}
MODIFICATION: cysteine residue {C1013}
cysteine residue {C1013}
MODIFICATION: cysteine residue {C998}
cysteine residue {C1021}
MODIFICATION: cysteine residue {C1052}
cysteine residue {C1052}
MODIFICATION: cysteine residue {C1021}
N-glycosylation site {N1060}
N-glycosylation site {N1071}
transmembrane domain {1091-1111}
GFFKR {1115-1119}
Database Correlations
OMIM 153370
UniProt P20701
PFAM correlations
Entrez Gene 3683
References
- UniProt :accession P20701
- Hibbs ML, Xu H, Stacker SA, Springer TA.
Regulation of adhesion of ICAM-1 by the cytoplasmic domain of
LFA-1 integrin beta subunit.
Science. 1991 Mar 29;251(5001):1611-3.
PMID: 1672776
- Cotran et al Robbins Pathologic Basis of Disease,
W.B. Saunders Co, Philadelphia, PA 1989 pg 165
- http://www.pathologyoutlines.com/cdmarkers.html
15 October 2002
- Entrez Gene :accession 3683
Component-of
lymphocyte function-associated antigen-1 (LFA-1, leukocyte adhesion protein LFA-1, integrin alpha-L/beta-2, CD11a/CD18)