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CC chemokine receptor type 7; C-C CKR-7; CC-CKR-7; CCR-7; MIP-3 beta receptor; EBV-induced G-protein coupled receptor 1; EBI1; BLR2; CDw197; CD197 (CCR7, CMKBR7, EBI1, EVI1)
Function:
- receptor for the MIP-3-beta chemokine
- probable mediator of normal lymphocyte functions
Structure: belongs to the G-protein coupled receptor 1 family
Compartment: cell membrane
Expression:
- expressed in various lymphoid tissues & activated B-cells & T-cells
Pathology:
- probable mediator of EBV effects on B-lymphocytes
- up-regulated in B-cells infected with Epstein-Barr virus & T-cells infected with Herpesvirus 6 or 7
Interactions
molecular events
General
CC chemokine receptor
cluster-of-differentiation antigen; cluster designation antigen; CD antigen
glycoprotein
phosphoprotein
Properties
SIZE: entity length = 378 aa
MW = 43 kD
COMPARTMENT: plasma membrane
MOTIF: signal sequence {1-24}
exoplasmic domain {25-59}
MOTIF: N-glycosylation site {N36}
transmembrane domain {60-86}
cytoplasmic loop {87-95}
transmembrane domain {96-116}
exoplasmic loop {117-130}
MOTIF: cysteine residue {C129}
MODIFICATION: cysteine residue {C210}
transmembrane domain {131-152}
MOTIF: Ser phosphorylation site {S151}
cytoplasmic loop {153-170}
transmembrane domain {171-191}
exoplasmic loop {192-219}
MOTIF: cysteine residue {C210}
MODIFICATION: cysteine residue {C129}
transmembrane domain {220-247}
cytoplasmic loop {248-263}
transmembrane domain {264-289}
exoplasmic loop {290-313}
transmembrane domain {314-331}
cytoplasmic domain {332-378}
Database Correlations
OMIM 600242
UniProt P32248
Pfam PF00001
Entrez Gene 1236
Kegg hsa:1236
References
- UniProt :accession P32248
- Wikipedia; CC chemokine receptors entry
http://en.wikipedia.org/wiki/CC_chemokine_receptors
Component-of
molecular complex