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C-C chemokine receptor type 6; C-C CKR-6; CC-CKR-6; CCR-6; LARC receptor; GPR-CY4; GPRCY4; chemokine receptor-like 3; CKR-L3; DRY6; G-protein coupled receptor 29; CD196 (CCR6, CKRL3, CMKBR6, GPR29, STRL22)
Function:
- receptor for a C-C type chemokine
- binds to MIP-3- alpha/LARC
- transduces a signal by increasing the intracellular Ca+2
Structure: belongs to the G-protein coupled receptor 1 family
Compartment: cell membrane
Expression:
- expressed in spleen, lymph nodes, appendix, & fetal liver
- expressed in lymphocytes, T-cells & B-cells but not in natural killer cells, monocytes or granulocytes
- induced by interleukin-2
Note: uncertain whether Met-1 or Met-6 is the initiator
Interactions
molecular events
General
CC chemokine receptor
cluster-of-differentiation antigen; cluster designation antigen; CD antigen
glycoprotein
Properties
SIZE: entity length = 374 aa
MW = 42 kD
COMPARTMENT: plasma membrane
MOTIF: exoplasmic domain {1-47}
MOTIF: N-glycosylation site {N7}
N-glycosylation site {N23}
transmembrane domain {48-74}
cytoplasmic loop {75-83}
transmembrane domain {84-104}
exoplasmic loop {105-119}
MOTIF: cysteine residue {C118}
MODIFICATION: cysteine residue {C197}
transmembrane domain {120-141}
cytoplasmic loop {142-159}
transmembrane domain {160-180}
exoplasmic loop {181-211}
MOTIF: cysteine residue {C197}
MODIFICATION: cysteine residue {C118}
transmembrane domain {212-238}
cytoplasmic loop {239-254}
transmembrane domain {255-279}
exoplasmic loop {280-303}
transmembrane domain {304-321}
cytoplasmic domain {322-374}
Database Correlations
OMIM 601835
UniProt P51684
Pfam PF00001
Entrez Gene 1235
Kegg hsa:1235
References
- UniProt :accession P51684
- Wikipedia; Note: CC chemokine receptors entry
http://en.wikipedia.org/wiki/CC_chemokine_receptors
Component-of
molecular complex