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C-C chemokine receptor type 4; C-C CKR-4; CC-CKR-4; CCR-4; CCR4; K5-5; CD194 (CCR4, CMKBR4)
Function:
- high affinity receptor for the C-C type chemokines CCL17/TARC & CCL22/MDC
- activity is mediated by Gi proteins which activate a phosphatidylinositol-Ca+2 second messenger system
- can function as a chemoattractant homing receptor on circulating memory lymphocytes
- in the CNS, could mediate hippocampal-neuron survival
- in natural killer cells, CCL22 binding induces phosphorylation on yet undefined Ser/Thr residues, probably by beta-adrenergic receptor kinases BARK1 & BARK2
Structure: belongs to the G-protein coupled receptor 1 family
Compartment: cell membrane
Expression:
- expressed in the thymus, in peripheral blood leukocytes, including T-cells, mostly CD4+ cells, & basophils, & in platelets > spleen, monocytes
- also detected in macrophages, IL-2-activated NK cells & skin-homing memory T-cells, mostly expressing cutaneous lymphocyte antigen (CLA)
- expressed in brain microvascular & coronary artery endothelial cells
Pathology:
- coreceptor for some primary HIV-2 isolates
Interactions
molecular events
General
CC chemokine receptor
cluster-of-differentiation antigen; cluster designation antigen; CD antigen
glycoprotein
Properties
SIZE: entity length = 360 aa
MW = 41 kD
COMPARTMENT: plasma membrane
MOTIF: exoplasmic domain {1-39}
transmembrane domain {40-67}
cytoplasmic loop {68-77}
transmembrane domain {78-98}
exoplasmic loop {99-111}
MOTIF: cysteine residue {C110}
MODIFICATION: cysteine residue {C187}
transmembrane domain {112-133}
cytoplasmic loop {134-150}
transmembrane domain {151-175}
exoplasmic loop {176-206}
MOTIF: N-glycosylation site {N183}
cysteine residue {C187}
MODIFICATION: cysteine residue {C110}
N-glycosylation site {N194}
transmembrane domain {207-226}
cytoplasmic loop {227-242}
transmembrane domain {243-267}
exoplasmic loop {268-284}
transmembrane domain {285-308}
cytoplasmic domain {309-360}
Database Correlations
OMIM 604836
UniProt P51679
Pfam PF00001
Entrez Gene 1233
Kegg hsa:1233
References
- UniProt :accession P51679
- Wikipedia; CC chemokine receptors entry
http://en.wikipedia.org/wiki/CC_chemokine_receptors