Search
C-C chemokine receptor type 1; C-C CKR-1; CC-CKR-1; CCR-1; CCR1; macrophage inflammatory protein 1-alpha receptor; MIP-1alpha-R; RANTES-R; HM145; LD78 receptor; CD191 (CCR1, CMKBR1, CMKR1, SCYAR1)
Function:
- receptor for a C-C type chemokine
- binds to MIP-1-alpha, MIP-1-delta, RANTES, & MCP-3 &, less efficiently, to MIP-1- beta or MCP-1
- upon ligand binding, transduces a signal by increasing intracellular Ca+2 level
- role in stem cell proliferation
Structure: belongs to the G-protein coupled receptor 1 family
Compartment: cell membrane
Expression:
- widely expressed in different hematopoietic cells
Interactions
molecular events
General
CC chemokine receptor
cluster-of-differentiation antigen; cluster designation antigen; CD antigen
glycoprotein
Properties
SIZE: entity length = 355 aa
MW = 41 kD
COMPARTMENT: plasma membrane
MOTIF: exoplasmic domain {1-34}
MOTIF: N-glycosylation site {N5}
transmembrane domain {35-60}
cytoplasmic loop {61-64}
transmembrane domain {65-91}
exoplasmic loop {92-107}
MOTIF: cysteine residue {C106}
MODIFICATION: cysteine residue {C183}
transmembrane domain {108-129}
cytoplasmic loop {130-146}
transmembrane domain {147-171}
exoplasmic loop {172-197}
MOTIF: cysteine residue {C183}
MODIFICATION: cysteine residue {C106}
transmembrane domain {198-223}
cytoplasmic loop {224-239}
transmembrane domain {240-264}
exoplasmic loop {265-281}
transmembrane domain {282-305}
cytoplasmic domain {306-355}
References
- UniProt :accession P32246
- Wikipedia; CC chemokine receptors entry
http://en.wikipedia.org/wiki/CC_chemokine_receptors
Databases & Figures
OMIM 601159
UniProt P32246
Pfam PF00001
Entrez Gene 1230
Kegg hsa:1230
CC ligand and receptor binding