CCR4-NOT transcription complex subunit 1 (negative regulator of transcription subunit 1 homolog, NOT1H, hNOT1, CCR4-associated factor 1, CNOT1, CDC39, KIAA1007, NOT1, AD-005)

Function: - belongs to the CCR4-NOT complex - acts as a transcriptional repressor - represses the ligand-dependent transcriptional activation by nuclear receptors - interacts in a ligand-dependent fashion with ESR1 & RXRA Structure: belongs to the CNOT1 family Alternative splicing: named isoforms=4 Expression: - strongly expressed in brain, heart, thymus, spleen, kidney, liver, placenta & lung - weakly expressed in skeletal muscle & colon

General

protein subunit transcriptional silencer (transcriptional repressor)

Properties

SIZE: entity length = 2376 aa MW = 267 kD MOTIF: threonine-rich region {1333-1350} MOTIF: threonine residue (SEVERAL)

Database Correlations

OMIM 604917 UniProt A5YKK6 Pfam PF04054

References

UniProt :accession A5YKK6