CCR4-NOT core complex

Ubiquitous general transcription regulation complex. Function: - one of the major cellular mRNA deadenylases - linked to various cellular processes including - bulk mRNA degradation - miRNA-mediated repression - translational repression during translational initiation - general transcription regulation. Structure: - subunits include: - CHAF1A, CHAF1B, CNOT1, CNOT2, CNOT3, CNOT4, CNOT6, CNOT6L, CNOT7, CNOT8, CNOT9, CNOT10, CNOT11, TNKS1BP1 - distinct complexes seem to exist that differ in probably mutually exclusive catalytic subunits [2]

Properties

SUBUNITS: chromatin assembly factor 1 subunit A COMPARTMENT: cell nucleus MOTIF: binding site SITE: 1-314 FOR-BINDING-OF: chromobox protein homolog 1 MOTIF: binding site SITE: 1-49 FOR-BINDING-OF: proliferating cell nuclear antigen Ser phosphorylation site {S65} Ser phosphorylation site {S123} Ser phosphorylation site {S138} Ser phosphorylation site {S141} Ser phosphorylation site {S143} Ser phosphorylation site {S206} Ser phosphorylation site {S224} PxVxL {233-246} lysine-rich region {323-453} MOTIF: lysine residue (SEVERAL) glutamate-rich region {602-608} MOTIF: glutamate residue (SEVERAL) homodimerization {642-678} binding site SITE: 60-956 FOR-BINDING-OF: chromatin assembly factor 1 subunit B MOTIF: Thr phosphorylation site {T722} Ser phosphorylation site {S772} Ser phosphorylation site {S775} Thr phosphorylation site {T865} Ser phosphorylation site {S873} glutamate-rich region {905-911} MOTIF: glutamate residue (SEVERAL) Ser phosphorylation site {S951} chromatin assembly factor 1 subunit B COMPARTMENT: cytoplasm cell nucleus MOTIF: WD repeat {11-54} WD repeat {64-103} WD repeat {127-166} WD repeat {169-208} WD repeat {228-279} WD repeat {299-340} WD repeat {344-385} Ser phosphorylation site {S409} Thr phosphorylation site {T419} Ser phosphorylation site {S429} Thr phosphorylation site {T433} Ser phosphorylation site {S458} Thr phosphorylation site {T495} Thr phosphorylation site {T509} Thr phosphorylation site {T521} Thr phosphorylation site {T531} Ser phosphorylation site {S538} CCR4-NOT transcription complex subunit 2 COMPARTMENT: cytoplasm cell nucleus MOTIF: Ser phosphorylation site {S101} CCR4-NOT transcription complex subunit 3 COMPARTMENT: cytoplasm cell nucleus MOTIF: Ser phosphorylation site {S299} proline-rich region SITE: 314-395 MOTIF: proline residue (SEVERAL) serine-rich region {397-425} MOTIF: serine residue (SEVERAL) proline-rich region SITE: 457-655 MOTIF: proline residue (SEVERAL) CCR4-NOT transcription complex subunit 4 COMPARTMENT: cytoplasm cell nucleus MOTIF: RING-finger {14-57} EFFECTOR-BOUND: Zn+2 FOR-BINDING-OF: DNA motif coiled coil {68-104} MOTIF: Ser phosphorylation site {S71} RNP motif NAME: RNP motif SITE: 109-189 FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif NAME: ribonucleoprotein-1 motif FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif ribonucleoprotein-2 motif ribonucleoprotein-2 motif FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif ribonucleoprotein-2 motif Zinc finger NAME: Zinc finger SITE: 190-217 EFFECTOR-BOUND: Zn+2 Ser phosphorylation site {S324} Ser phosphorylation site {S432} Ser phosphorylation site {S490} CCR4-NOT transcription complex subunit 6 COMPARTMENT: cytoplasm cell nucleus MOTIF: leucine-rich repeat SITE: 50-73 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 75-95 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 96-122 MOTIF: leucine residue (SEVERAL) Mg+2-binding site SITE: 240-240 CCR4-NOT transcription complex subunit 6-like COMPARTMENT: cytoplasm MOTIF: leucine-rich repeat SITE: 55-78 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 80-101 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 103-127 MOTIF: leucine residue (SEVERAL) CCR4-NOT transcription complex subunit 7 COMPARTMENT: cell nucleus CCR4-NOT transcription complex subunit 8 CCR4-NOT transcription complex subunit 10 MOTIF: coiled coil {74-107} CCR4-NOT transcription complex subunit 11 COMPARTMENT: cytoplasm cell nucleus MOTIF: glycine-rich region {3-59} proline-rich region SITE: 155-180 MOTIF: proline residue (SEVERAL) proline-rich region SITE: 287-290 MOTIF: proline residue (SEVERAL) 182 kD tankyrase-1-binding protein COMPARTMENT: cytoplasm cell nucleus MOTIF: proline-rich region SITE: 2-103 MOTIF: proline residue (SEVERAL) proline-rich region SITE: 127-767 MOTIF: proline residue (SEVERAL) Ser phosphorylation site {S178} Acidic {210-1572} MOTIF: Ser phosphorylation site {S221} Ser phosphorylation site {S228} Thr phosphorylation site {T239} Ser phosphorylation site {S287} Ser phosphorylation site {S301} Ser phosphorylation site {S429} Ser phosphorylation site {S435} Ser phosphorylation site {S437} Ser phosphorylation site {S494} Ser phosphorylation site {S498} Ser phosphorylation site {S504} Ser phosphorylation site {S518} Ser phosphorylation site {S601} Ser phosphorylation site {S672} Ser phosphorylation site {S691} Ser phosphorylation site {S695} Ser phosphorylation site {S712} Ser phosphorylation site {S714} Ser phosphorylation site {S744} Ser phosphorylation site {S762} Ser phosphorylation site {S806} Thr phosphorylation site {T833} Ser phosphorylation site {S836} Ser phosphorylation site {S872} Ser phosphorylation site {S893} Ser phosphorylation site {S920} Ser phosphorylation site {S936} Ser phosphorylation site {S976} Thr phosphorylation site {T979} Ser phosphorylation site {S983} Ser phosphorylation site {S987} Ser phosphorylation site {S1008} glycine-rich region {1010-1340} Ser phosphorylation site {S1024} Ser phosphorylation site {S1029} Ser phosphorylation site {S1093} Ser phosphorylation site {S1103} Ser phosphorylation site {S1133} Ser phosphorylation site {S1138} Ser phosphorylation site {S1141} Ser phosphorylation site {S1178} Ser phosphorylation site {S1181} Ser phosphorylation site {S1248} Thr phosphorylation site {T1282} Ser phosphorylation site {S1297} Ser phosphorylation site {S1328} Ser phosphorylation site {S1331} Ser phosphorylation site {S1383} Ser phosphorylation site {S1385} Ser phosphorylation site {S1405} Ser phosphorylation site {S1439} binding site SITE: 1450-1542 FOR-BINDING-OF: tankyrase Ser phosphorylation site {S1452} Ser phosphorylation site {S1473} Ser phosphorylation site {S1476} Ser phosphorylation site {S1533} Ser phosphorylation site {S1545} Ser phosphorylation site {S1552} Ser phosphorylation site {S1554} Ser phosphorylation site {S1558} Thr phosphorylation site {T1563} lysine-rich region {1572-1729} MOTIF: lysine residue (SEVERAL) Ser phosphorylation site {S1616} Ser phosphorylation site {S1620} Ser phosphorylation site {S1621} nuclear translocation signal {1629-1635} Ser phosphorylation site {S1652} Ser phosphorylation site {S1654} Ser phosphorylation site {S1666} Ser phosphorylation site {S1715} nuclear translocation signal {1723-1729}

Components

182 kD tankyrase-1-binding protein (TNKS1BP1, KIAA1741, TAB182) CCR4-NOT transcription complex subunit 1 (negative regulator of transcription subunit 1 homolog, NOT1H, hNOT1, CCR4-associated factor 1, CNOT1, CDC39, KIAA1007, NOT1, AD-005) CCR4-NOT transcription complex subunit 10 (CNOT10) CCR4-NOT transcription complex subunit 11 (CNOT11, C2orf29, C40) CCR4-NOT transcription complex subunit 2 (CCR4-associated factor 2, CNOT2, CDC36, NOT2, HSPC131, MSTP046) CCR4-NOT transcription complex subunit 3 (CCR4-associated factor 3, leukocyte receptor cluster member 2, CNOT3, KIAA0691, NOT3) CCR4-NOT transcription complex subunit 4; CCR4-associated factor 4; E3 ubiquitin-protein ligase CNOT4; transcriptional repressor NOT4Hp (CNOT4, NOT4) CCR4-NOT transcription complex subunit 6 (cytoplasmic deadenylase, carbon catabolite repressor protein 4 homolog, CCR4 carbon catabolite repression 4-like, CNOT6, CCR4, KIAA1194) CCR4-NOT transcription complex subunit 6-like (carbon catabolite repressor protein 4 homolog B, CNOT6L, CCR4B) CCR4-NOT transcription complex subunit 7 (CCR4-associated factor 1, CAF1, BTG1-binding factor 1, CNOT7) CCR4-NOT transcription complex subunit 8 (CCR4-associated factor 8, CAF1-like protein, CALIFp, CAF2, CNOT8, CALIF, POP2) chromatin assembly factor 1 subunit A; CAF-1 subunit A; chromatin assembly factor I p150 subunit; CAF-I 150 kDa subunit; CAF-Ip150 (CHAF1A, CAF, CAF1P150) chromatin assembly factor 1 subunit B; CAF-1 subunit B; chromatin assembly factor I p60 subunit; CAF-I 60 kD subunit; CAF-Ip60; M-phase phosphoprotein 7 (CHAF1B, CAF1A, CAF1P60, MPHOSPH7, MPP7)