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gastrin/cholecystokinin type B receptor; CCK-B receptor; CCK-BR; cholecystokinin-2 receptor; CCK2-R (CCKBR, CCKRB)

Function: - receptor for gastrin & cholecystokinin - the CKK-B receptors occur throughout the CNS where they modulate anxiety, analgesia, arousal, & neuroleptic activity - mediates its action by association with G proteins that activate a phosphatidylinositol-Ca+2 second messenger system - isoform 2 may regulate cancer cell proliferation via a gastrin-independent mechanism Structure: belongs to the G-protein coupled receptor 1 family Compartment: cell membrane Alternative splicing: named isoforms=3 Expression: - isoform 1 is expressed in brain, pancreas, stomach, - within the stomach, expressed at high levels in the mucosa of the gastric fundus & at low levels in the antrum & duodenum - isoform 1 is not expressed in heart, placenta, liver, lung, skeletal muscle, or kidney - isoform 3 is expressed in brain, pancreas, stomach Pathology: - isoform 1 is expressed in the colon cancer cell line LoVo & the T-lymphoblastoma Jurkat, but not in the stomach cancer cell line AGS - expressed at high levels in the small cell lung cancer cell line H510, at lower levels in H345, H69 & GLC28 - not expressed in GLC19 - isoform 2 is present in pancreatic cancer cells & colorectal cancer cells, but not in normal pancreas or colonic mucosa - isoform 3 is expressed in the stomach cancer cell line AGS & the colon cancer cell line LoVo; it is also expressed in normal stomach

General

cholecystokinin [CCK] receptor glycoprotein G-protein coupled receptor; serpentine receptor

Properties

SIZE: entity length = 447 aa MW = 48 kD COMPARTMENT: plasma membrane MOTIF: exoplasmic domain {1-57} MOTIF: N-glycosylation site {N7} N-glycosylation site {N30} N-glycosylation site {N36} transmembrane domain {58-79} cytoplasmic loop {80-87} transmembrane domain {88-109} exoplasmic loop {110-131} MOTIF: cysteine residue {C127} MODIFICATION: cysteine residue {C205} transmembrane domain {132-150} cytoplasmic loop {151-170} transmembrane domain {171-189} exoplasmic loop {190-219} MOTIF: cysteine residue {C205} MODIFICATION: cysteine residue {C127} transmembrane domain {220-242} cytoplasmic loop {243-333} transmembrane domain {334-355} exoplasmic loop {356-373} transmembrane domain {374-394} cytoplasmic domain {395-447} MOTIF: cysteine residue {C408} MODIFICATION: palmitate COMPARTMENT: membrane

Database Correlations

OMIM 118445 UniProt P32239 Pfam PF00001 Kegg hsa:887

References

  1. UniProt :accession P32239
  2. Wikipedia; Note: cholecystokinin receptor entry http://en.wikipedia.org/wiki/cholecystokinin_receptor