homeobox protein cut-like 1; CCAAT displacement protein; CDP; homeobox protein cux-1 (CUX1, CUTL1)

Function: - probably has a broad role in mammalian development as a repressor of developmentally regulated gene expression - may act by preventing binding of positively-activing CCAAT factors to promoters - component of nf-munr repressor - binds to the matrix attachment regions (MARs) (5' & 3') of the immunoglobulin heavy chain enhancer - represses T-cell receptor (TCR) beta enhancer function by binding to MARbeta, an ATC-rich DNA sequence located upstream of the TCR beta enhancer (putative) - interacts with BANP (putative) - phosphorylated upon DNA damage, probably by ATM or ATR Structure: - belongs to the CUT homeobox family - contains 3 CUT DNA-binding domains - contains 1 homeobox DNA-binding domain - Asn-1290 may participate in regulating DNA-binding activity by promoting homo- & heterodimerization Compartment: nucleus Alternative splicing: - named isoforms=7 - additional isoforms seem to exist Note: - both the CASP protein & the CCAAT displacement protein appear to have the gene symbol CUX1 with synonym CUTL1

General

DNA-binding protein phosphoprotein

Properties

SIZE: entity length = 1505 aa MW = 164 kD COMPARTMENT: cell nucleus MOTIF: coiled coil {7-363} MOTIF: Ser phosphorylation site {S322} DNA-binding motif SITE: 542-629 coiled coil {669-725} DNA-binding motif SITE: 934-1021 Ser phosphorylation site {S1054} Ser phosphorylation site {S1059} DNA-binding motif SITE: 1117-1204 Ser phosphorylation site {S1218} Tyr phosphorylation site {Y1232} Ser phosphorylation site {S1233} homeodomain SITE: 1244-1303 Ser phosphorylation site {S1312} Ser phosphorylation site {S1496}

Database Correlations

OMIM 116896 UniProt P39880 PFAM correlations Entrez Gene 1523 Kegg hsa:1523

References

UniProt :accession P39880