Cbp/p300-interacting transactivator 4 (MSG1-related protein 2, MRG-2, CITED4 MRG2)

Function: 1) transcriptional coactivator for TFAP2/AP-2 2) inhibitor of transactivation by HIF1A by disrupting HIF1A interaction with CREBBP (putative) 3) role in regulation of gene expression during development & differentiation of blood cells, endothelial cells & mammary epithelial cells 4) interacts via its C-terminal region with the CH1 domain of CREBBP & EP300 5) interacts with all TFAP2/AP-2 isoforms Structure: - belongs to the CITED family Compartment: nucleus, cytoplasm Expression: - expressed in most tissues - highest levels of expression in heart, liver, skeletal muscle, pancreas Pathology: - expressed in bladder cell line ECV304 & in various breast cancer cell lines - expression is down-regulated & mostly restricted to the cytoplasm of malignant epithelium in invasive breast tumors - down-regulation of expression is associated with elevated levels of HIF1A and increased tumor growth & angiogenesis

Properties

SIZE: MW = 19 kD entity length = 184 aa COMPARTMENT: cytoplasm cell nucleus MOTIF: proline-rich region SITE: 17-125 MOTIF: proline residue (SEVERAL)

Database Correlations

OMIM 606815 UniProt Q96RK1 Pfam PF04487

References

UniProt :accession Q96RK1