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core-binding factor [CBF]-alpha 3; runt-related transcription factor 3; acute myeloid leukemia 2 protein; polyomavirus enhancer binding protein 2 alpha C subunit; SL3-3 enhancer factor 1 alpha C subunit; SL3/AKV core-binding factor alpha C subunit (RUNX3, AML2, CBFA3, PEBP2A3)
Function:
- CBF binds to the core site, 5'-PYGPYGGT-3', of a number of enhancers & promoters, including
a) murine leukemia virus
b) polyomavirus enhancer
c) T-cell receptor enhancers
d) osteocalcin
e) osteopontin
f) bone sialoprotein
g) collagen-1 alpha-1
h) LCK
i) IL-3
j) GM-CSF promoters
- CBF-alpha binds DNA as a monomer & through the Runt domain
- DNA-binding is increased by heterodimerization
- interacts with TLE1 & SUV39H1
Structure:
- heterodimer of CBF-alpha & CBF-beta subunit
- proline/serine/threonine rich region at the C-terminus is necessary for transcriptional activation of target genes
- contains 1 Runt domain
Compartment: nucleus
Alternative splicing: named isoforms=2
General
core-binding factor [CBF]-alpha (PEBP2-alpha)
phosphoprotein
Properties
SIZE: entity length = 415 aa
MW = 44 kD
COMPARTMENT: cell nucleus
MOTIF: glycine-rich region {23-27}
Runt {54-182}
threonine-rich region {191-415}
MOTIF: threonine residue (SEVERAL)
Ser phosphorylation site {S243}
Database Correlations
OMIM 600210
UniProt Q13761
PFAM correlations
Entrez Gene 864
Kegg hsa:864
References
- UniProt :accession Q13761
- OMIM :accession 600210