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core-binding factor [CBF]-alpha (PEBP2-alpha)
Function:
- alpha subunit of core-binding factor
- CBF binds to the core site, 5'-PYGPYGGT-3', of a number of enhancers & promoters, including
a) murine leukemia virus
b) polyomavirus enhancer
c) T-cell receptor enhancers
d) osteocalcin
e) osteopontin
f) bone sialoprotein
g) collagen-1 alpha-1
h) LCK
i) IL-3
j) GM-CSF promoters
- CBF-alpha binds DNA as a monomer & through the Runt domain
- DNA-binding is increased by heterodimerization
Specific
core-binding factor [CBF]-alpha 1; runt-related transcription factor 2; RUNX2; acute myeloid leukemia 3 [AML3] protein; polyomavirus enhancer binding protein 2 alpha A subunit; PEBP2-alpha A; SL3-3 enhancer factor 1 alpha A subunit; SL3/AKV core-binding factor alpha A subunit; osteoblast-specific transcription factor 2; OSF-2 (RUNX2, AML3, CBFA1, OSF2, PEBP2A)
core-binding factor [CBF]-alpha 2; runt-related transcription factor 1; acute myeloid leukemia 1 protein; polyomavirus enhancer binding protein 2 alpha B subunit; PEBP2-alpha B; SL3-3 enhancer factor 1 alpha B subunit;SL3/AKV core-binding factor alpha B subunit (RUNX1, AML1, CBFA2)
core-binding factor [CBF]-alpha 3; runt-related transcription factor 3; acute myeloid leukemia 2 protein; polyomavirus enhancer binding protein 2 alpha C subunit; SL3-3 enhancer factor 1 alpha C subunit; SL3/AKV core-binding factor alpha C subunit (RUNX3, AML2, CBFA3, PEBP2A3)
General
transcription factor (TF)
Properties
COMPARTMENT: cell nucleus
References
- Liu et al,
Fusion between transcription factor CBF beta/PEB2 beta and a
myosin heavy chain in acute myeloid leukemia.
Science 261:1041 1993
PMID: 8351518
- UniProt :accession Q13761
Component-of
core-binding factor (CBF) or polyoma virus enhancer-binding protein-2 (PEBP2)