CBF1-interacting corepressor; recepin (CIR, CIR1)

Function: 1) modulates splice site selection during alternative splicing of pre-mRNAs (putative) 2) regulates transcription & acts as corepressor for RBPSUH. 3) recruits RBPSUH to the Sin3-histone deacetylase complex 4) role in RBPSUH-mediated repression of transcription 5) interacts with RP9, SNW1, SFRS1, SFRS2 & U2AF1 6) component of histone deacetylase complex 7) interacts with RBPSUH, SAP30 & HDAC2 Alternative splicing: named isoforms=2 Expression: - expressed in heart, brain, placenta, liver, skeletal muscle, pancreas Pathology: - interacts with Epstein-Barr virus RPMS1

General

splicing factor; snRNP-associated protein transcriptional silencer (transcriptional repressor)

Properties

SIZE: MW = 52 kD entity length = 450 aa COMPARTMENT: cell nucleus MOTIF: interaction with RBPSUH {1-121} interaction with RP9 {204-232} serine-rich region {214-368} MOTIF: serine residue (SEVERAL) nuclear translocation signal {235-245} nuclear translocation signal {291-298} arginine/serine-rich region (RS domain) {369-450} MOTIF: serine residue (SEVERAL) arginine residue (SEVERAL)

Database Correlations

OMIM 605228 UniProt Q86X95

References

UniProt :accession Q86X95