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CBC(VHL) complex
Function:
- associated with elongin BC complex
- CBC(VHL) complex formation seems to promote neddylation of cullin (CUL2)
- involved in regulation of vascular endothelial growth factor mRNA
Structure:
- subunits include RBX1
- in association with elongin BC complex, contains TCEB1 & TCEB2, CUL2 or CUL5 & VHL
General
molecular complex
Properties
SUBUNITS: RING-box protein 1
COMPARTMENT: cytoplasm
cell nucleus
MOTIF: acetylation site
SITE: N-TERMINUS
EFFECTOR-BOUND: acetyl
Ser phosphorylation site {S11}
Zn+2-binding site
SITE: 42-42
Zn+2-binding site
SITE: 45-45
RING-finger {53-98}
MOTIF: Zn+2-binding site
SITE: 53-53
Zn+2-binding site
SITE: 56-56
Zn+2-binding site
SITE: 68-68
Zn+2-binding site
SITE: 75-75
Zn+2-binding site
SITE: 77-77
Zn+2-binding site
SITE: 80-80
Zn+2-binding site
SITE: 82-82
Zn+2-binding site
SITE: 83-83
Zn+2-binding site
SITE: 94-94
Zn+2-binding site
SITE: 97-97
EFFECTOR-BOUND: Zn+2
FOR-BINDING-OF: DNA motif
von Hippel-Lindau tumor suppressor
COMPARTMENT: cytoplasm
cell nucleus
MOTIF: repeat {14-53}
MOTIF: consensus repeat {14-18}
consensus repeat {19-23}
consensus repeat {24-28}
consensus repeat {29-33}
consensus repeat {34-38}
consensus repeat {39-43}
consensus repeat {44-48}
consensus repeat {49-53}
domain {100-155}
domain {157-166}
ENLONGIN-BC-COMPLEX
Cullin-2
MOTIF: Tyr phosphorylation site {Y394}
Thr phosphorylation site {T661}
References
UniProt :accession P62877
Components
Cullin-2; CUL-2 (CUL2)
RING-box protein 1; Rbx1; regulator of cullins 1; RING finger protein 75; protein ZYP (RBX1 RNF75 ROC1)
von Hippel-Lindau disease tumor suppressor; pVHL; protein G7 (VHL)