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cathepsin-Z (cathepsin P, cathepsin X, CTSZ)
Function:
- carboxypeptidase
- carboxy-monopeptidase & carboxy-dipeptidase activity
- release of C-terminal amino acid residues with broad specificity, but lacks action on C-terminal proline
- weak endopeptidase activity
Structure: belongs to the peptidase C1 family
Compartment: lysosome
Expression: widely expressed
General
cathepsin
glycoprotein
Properties
SIZE: MW = 34 kD
entity length = 303 aa
COMPARTMENT: lysosome
MOTIF: cysteine residue {C89}
MODIFICATION: cysteine residue {C132}
cysteine residue {C92}
cysteine residue {C126}
MODIFICATION: cysteine residue {C164}
cysteine residue {C132}
MODIFICATION: cysteine residue {C89}
cysteine residue {C154}
MODIFICATION: cysteine residue {C170}
cysteine residue {C164}
MODIFICATION: cysteine residue {C126}
cysteine residue {C170}
MODIFICATION: cysteine residue {C154}
cysteine residue {C173}
MODIFICATION: cysteine residue {C179}
cysteine residue {C179}
MODIFICATION: cysteine residue {C173}
N-glycosylation site {N184}
cysteine residue {C214}
MODIFICATION: cysteine residue {C296}
N-glycosylation site {N224}
histidine residue {H241}
asparagine residue {N261}
cysteine residue {C296}
MODIFICATION: cysteine residue {C214}
Database Correlations
OMIM 603169
UniProt Q9UBR2
Pfam PF00112
Entrez Gene 1522
Kegg hsa:1522
References
UniProt :accession Q9UBR2