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cathepsin-H (CTSH)
Function:
- role in overall degradation of proteins in lysosomes
- hydrolysis of proteins
- aminopeptidase (notably, cleaving Arg-|-Xaa bonds) & endopeptidase activity
Structure:
- composed of a mini chain & a large chain large chain may be split into heavy & light chain all chains are held together by disulfide bonds
- belongs to the peptidase C1 family
Compartment: lysosome
General
cathepsin
cysteine proteinase; thiol proteinase
glycoprotein
Properties
SIZE: entity length = 335 aa
MW = 37 kD
COMPARTMENT: lysosome
MOTIF: signal sequence {1-22}
N-glycosylation site {N101}
cysteine residue {C102}
MODIFICATION: cysteine residue {C327}
cysteine residue {C138}
MODIFICATION: cysteine residue {C181}
cysteine residue {C141}
cysteine residue {C172}
MODIFICATION: cysteine residue {C214}
cysteine residue {C181}
MODIFICATION: cysteine residue {C138}
cysteine residue {C214}
MODIFICATION: cysteine residue {C172}
N-glycosylation site {N230}
cysteine residue {C272}
MODIFICATION: cysteine residue {C322}
histidine residue {H281}
asparagine residue {N301}
cysteine residue {C322}
MODIFICATION: cysteine residue {C272}
cysteine residue {C327}
MODIFICATION: cysteine residue {C102}
Database Correlations
OMIM 116820
UniProt P09668
PFAM correlations
Entrez Gene 1512
Kegg hsa:1512
ENZYME 3.4.22.16
References
UniProt :accession P09668