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cathepsin-F (CTSF, CATSF)
Function:
- thiol protease
- role in intracellular degradation & turnover of proteins (putative)
- recombinant enzyme cleaves synthetic substrates with Phe & Leu (better than Val)
Structure: belongs to the peptidase C1 family
Compartment: lysosome
Expression:
- expressed in heart, skeletal muscle, brain, testis & ovary > prostate, placenta, liver & colon
- no detectable expression in peripheral leukocytes & thymus
Pathology:
- implicated in tumor invasion & metastasis
General
aspartic proteinase; carboxyl acid protease
cathepsin
glycoprotein
Properties
SIZE: entity length = 484 aa
MW = 53 kD
COMPARTMENT: lysosome
MOTIF: signal sequence {1-19}
N-glycosylation site {N160}
N-glycosylation site {N195}
cysteine residue {C292}
MODIFICATION: cysteine residue {C333}
cysteine residue {C295}
cysteine residue {C326}
MODIFICATION: cysteine residue {C366}
cysteine residue {C333}
MODIFICATION: cysteine residue {C292}
Thr phosphorylation site {T353}
Ser phosphorylation site {S365}
cysteine residue {C366}
MODIFICATION: cysteine residue {C326}
N-glycosylation site {N367}
N-glycosylation site {N378}
cysteine residue {C424}
MODIFICATION: cysteine residue {C472}
histidine residue {H431}
N-glycosylation site {N440}
asparagine residue {N451}
cysteine residue {C472}
MODIFICATION: cysteine residue {C424}
Database Correlations
OMIM 603539
UniProt Q9UBX1
PFAM correlations
Entrez Gene 8722
Kegg hsa:8722
ENZYME 3.4.22.41
References
UniProt :accession Q9UBX1