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CASK/TRB1/TSPYL2 transcriptional complex
Function:
- modulates gene expression in response to neuronal synaptic activity, probably by facilitating nucleosome assembly
Structure:
- subunits: CASK, TRB1 & TSPYL2
General
molecular complex
transcription factor (TF)
Properties
COMPARTMENT: cell nucleus
SUBUNITS: N-acetyltransferase 13
COMPARTMENT: cytoplasm
MOTIF: N-acetyltransferase {6-155}
MOTIF: Tyr phosphorylation site {Y110}
tyrosine residue {Y124}
N-terminal acetyltransferase complex ARD1 subunit homolog A
COMPARTMENT: cytoplasm
cell nucleus
MOTIF: N-acetyltransferase {1-152}
MOTIF: NARG1 interaction {1-58}
Ser phosphorylation site {S182}
Ser phosphorylation site {S186}
Ser phosphorylation site {S205}
NMDA receptor regulated protein 1
COMPARTMENT: cytoplasm
cell nucleus
MOTIF: tetratricopeptide repeat {46-79}
tetratricopeptide repeat {80-113}
tetratricopeptide repeat {148-184}
tetratricopeptide repeat {224-257}
tetratricopeptide repeat {374-407}
tetratricopeptide repeat {409-441}
tetratricopeptide repeat {485-518}
nuclear translocation signal {612-629}
tetratricopeptide repeat {672-705}
Thr phosphorylation site {T850}
Ser phosphorylation site {S855}
Ser phosphorylation site {S856}
References
UniProt :accession Q9H2G4
Components
N-acetyltransferase 13 (hNAT5, hSAN, NAT13, MAK3, NAT5, NAA50)
N-terminal acetyltransferase complex ARD1 subunit homolog A (ARD1A, ARD1, TE2, NAA10)
NMDA receptor-regulated protein 1; N-alpha-acetyltransferase 15, natA auxiliary subunit; gastric cancer antigen Ga19; N-terminal acetyltransferase; protein tubedown-1; Tbdn100 (NAA15, GA19, NARG1, NATH, TBDN100)