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CART complex
Function:
- necessary for efficient transferrin receptor recycling but not for EGFR degradation
Structure:
- subunits: ACTN4, HGS/HRS, MYO5B & TRIM3
General
molecular complex
Properties
SUBUNITS: alpha-actinin-4
CONFIGURATION: dimer
COMPARTMENT: cytoplasm
cell nucleus
MOTIF: actin-binding site
SITE: 1-269
FOR-BINDING-OF: F-actin
MOTIF: glycine-rich region {19-26}
calponin homology domain
NAME: calponin homology domain
SITE: 50-154
calponin homology domain
NAME: calponin homology domain
SITE: 163-269
binding site
SITE: 177-192
FOR-BINDING-OF: phosphatidylinositol-4,5-phosphate
Tyr phosphorylation site {Y265}
spectrin repeat {293-403}
spectrin repeat {413-518}
spectrin repeat {528-639}
spectrin repeat {649-752}
EF hand
SITE: 765-800
MOTIF: Ca+2-binding site
SITE: 778-789
EF hand
SITE: 806-841
MOTIF: Ca+2-binding site
SITE: 819-830
hepatocyte growth factor-regulated tyrosine kinase substrate
COMPARTMENT: cytoplasm
MOTIF: VHS domain {15-143}
MOTIF: Tyr phosphorylation site {Y132}
Zn finger Fyve-type
SITE: 160-220
EFFECTOR-BOUND: Zn+2
MOTIF: Tyr phosphorylation site {Y216}
SNX1 interaction {225-543}
MOTIF: Ser phosphorylation site {S240}
UIM {258-277}
Tyr phosphorylation site {Y286}
Tyr phosphorylation site {Y289}
Tyr phosphorylation site {Y308}
Tyr phosphorylation site {Y329}
Tyr phosphorylation site {Y334}
proline-rich region
SITE: 346-394
MOTIF: proline residue (SEVERAL)
SNAP25/TRAK2 interaction {445-543}
STAM1 interaction {454-572}
NF2 interaction {480-777}
MOTIF: glutamine-rich region {505-772}
MOTIF: glutamine residue (SEVERAL)
myosin-5b
MOTIF: Myosin head-like {1-764}
MOTIF: ATP-binding site
NAME: ATP-binding site
SITE: 163-170
actin-binding site
SITE: 640-662
FOR-BINDING-OF: F-actin
Tyr phosphorylation site {Y694}
IQ motif {769-798}
IQ motif {792-821}
arginine-rich region {801-916}
MOTIF: arginine residue (SEVERAL)
IQ motif {817-848}
IQ motif {840-869}
IQ motif {865-896}
IQ motif {888-917}
coiled coil {899-1266}
coiled coil {1341-1471}
MOTIF: Ser phosphorylation site {S1446}
Dilute {1526-1803}
tripartite motif-containing protein 3
COMPARTMENT: cytoplasm
MOTIF: acetylation site
SITE: N-TERMINUS
EFFECTOR-BOUND: acetyl
Ser phosphorylation site {S7}
RING-finger {22-63}
EFFECTOR-BOUND: Zn+2
FOR-BINDING-OF: DNA motif
zinc finger B box
SITE: 110-151
EFFECTOR-BOUND: Zn+2
coiled coil {153-224}
filamin repeat {317-418}
Ser phosphorylation site {S437}
Ser phosphorylation site {S443}
NHL repeat domain {473-516}
NHL repeat domain {520-563}
NHL repeat domain {564-605}
NHL repeat domain {609-652}
NHL repeat domain {656-699}
NHL repeat domain {700-743}
References
UniProt :accession O75382
Components
alpha-actinin-4; non-muscle alpha-actinin 4; F-actin cross-linking protein (ACTN4)
hepatocyte growth factor-regulated tyrosine kinase substrate; protein pp110 (Hrs, HGS)
myosin-5b (MYO5B, KIAA1119)
tripartite motif-containing protein 3; RING finger protein 22; brain-expressed RING finger protein; RING finger protein 97 (TRIM3, BERP, RNF22, RNF97)