cartilage intermediate layer protein 2 (CILP-2, CILP2)

Function: 1) role in cartilage scaffolding 2) may be cleaved into 2 chains possibly by a furin-like protease upon or preceding secretion Structure: - contains 1 Ig-like C2-type (immunoglobulin-like) domain. - contains 1 TSP type-1 domain Compartment: secreted, extracellular matrix Expression: - expressed in articular chondrocytes - not expressed in knee meniscal cartilage cells

General

glycoprotein secreted protein

Properties

SIZE: MW = 126 kD entity length = 1156 aa COMPARTMENT: extracellular compartment MOTIF: signal sequence {1-20} TSP type-1 {146-197} MOTIF: cysteine residue {C158} MODIFICATION: cysteine residue {C191} cysteine residue {C162} MODIFICATION: cysteine residue {C196} cysteine residue {C173} MODIFICATION: cysteine residue {C181} cysteine residue {C181} MODIFICATION: cysteine residue {C173} cysteine residue {C191} MODIFICATION: cysteine residue {C158} cysteine residue {C196} MODIFICATION: cysteine residue {C162} N-glycosylation site {N276} immunoglobulin superfamily domain {292-376} MOTIF: N-glycosylation site {N308} cysteine residue {C313} MODIFICATION: cysteine residue {C359} N-glycosylation site {N329} cysteine residue {C359} MODIFICATION: cysteine residue {C313}

Database Correlations

UniProt Q8IUL8 PFAM correlations

References

UniProt :accession Q8IUL8