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chitinase-3-like protein 1; cartilage glycoprotein 39; CGP-39; GP-39; hCGP-39; 39 kD synovial protein; YKL-40 (CHI3L1)
Function:
- carbohydrate-binding lectin with a preference for chitin
- may play a role in defense against pathogens, or in tissue remodeling
- may play an important role in the capacity of cells to respond to & cope with changes in their environment
- glycosylated
Structure:
- monomer
- belongs to the glycosyl hydrolase 18 family
Compartment: secreted, extracellular space
Expression:
- present in activated macrophages, articular chondrocytes, synovial cells as well as in liver
- undetectable in muscle tissues, lung, pancreas, mononuclear cells, or fibroblasts
Pathology:
- genetic variation in CHI3L1 is associated with susceptibility to asthma-related traits type 7
General
glycoprotein
secreted protein
Properties
SIZE: entity length = 383 aa
MW = 43 kD
COMPARTMENT: extracellular compartment
MOTIF: signal sequence {1-21}
cysteine residue {C26}
MODIFICATION: cysteine residue {C51}
cysteine residue {C51}
MODIFICATION: cysteine residue {C26}
N-glycosylation site {N60}
Chitooligosaccharide binding {70-71}
Chitooligosaccharide binding {97-100}
binding site
SITE: 141-141
FOR-BINDING-OF: Chitooligosaccharide
Chitooligosaccharide {204-207}
binding site
SITE: 263-263
FOR-BINDING-OF: Chitooligosaccharide
cysteine residue {C300}
MODIFICATION: cysteine residue {C364}
binding site
SITE: 352-352
FOR-BINDING-OF: Chitooligosaccharide
cysteine residue {C364}
MODIFICATION: cysteine residue {C300}
Database Correlations
OMIM correlations
MORBIDMAP 601525
UniProt P36222
Pfam PF00704
Entrez Gene 1116
Kegg hsa:1116
References
UniProt :accession P36222