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carnitine deficiency

Pathology: - disorder of fatty acid oxidation caused by defective carnitine transport Genetics: - autosomal recessive - defect in organic cation/carnitine transporter 2 (SLC22A5) Clinical manifestations: - systemic primary carnitine deficiency presents either: a) early in life with hypoketotic hypoglycemia & acute metabolic decompensation b) later in life with skeletal myopathy or cardiomyopathy Laboratory: - serum glucose may show hypoglycemia - serum ketones negative - acylcarnitines in serum/plasma low or absent

General

inborn error of metabolism

Database Correlations

OMIM correlations MORBIDMAP 603377

References

OMIM :accession 249270