Search
cardiotrophin-like cytokine factor 1 (B cell-stimulating factor 3, BSF-3, novel neurotrophin-1, NNT-1, CLCF1, BSF3, CLC, NNT1)
Function:
1) cytokine with B-cell stimulating capability
2) binds to & activates the ILST/gp130 receptor
3) component of CRLF1-CLCF1 complex
Compartment: secreted
Expression:
- expressed in lymph nodes, spleen, peripheral blood lymphocytes, bone marrow, fetal liver
Pathology:
- defects in CRLF1 result in cold-induced sweating syndrome 2 (CISS2)
Related
cold-induced sweating syndrome (CISS)
General
glycoprotein
secreted protein
Properties
COMPARTMENT: extracellular compartment
MOTIF: glycosylation site
Database Correlations
OMIM 607672
MORBIDMAP 607672
UniProt Q9UBD9
Pfam PF06875
References
UniProt :accession Q9UBD9
Component-of
CRLF1/CLCF1 complex