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cardiac microvascular dysfunction

A term distinguished from microvascular disease of diabetes mellitus Pathology: - refers to disease of small arteries (< 0.5 mm in diameter) accounting for 70% of coronary resistance in the absence of obstructive coronary artery disease Clinical manifestations: - patients may present with stable angina pectoris Special laboratory: - may present as false positive exercise ECG stress test [2] - abnormal response to acetylcholine infusion (endothelium-dependent) - abnormal response to adenosine infusion (endothelium-independent) [2]

Related

microvascular

General

microvascular disease heart disease (cardiac disease)

References

  1. Medical Knowledge Self Assessment Program (MKSAP) 19 American College of Physicians, Philadelphia 2022
  2. Sinha A et al. Rethinking false positive exercise electrocardiographic stress tests by assessing microvascular function. J Am Coll Cardiol 2024 Jan 16; 83:291. PMID: 38199706 PMCID: PMC10790243 Free PMC article https://www.sciencedirect.com/science/article/pii/S0735109723080191 - Beltrame JF et al. Clinical utility of the humble exercise ECG stress test. J Am Coll Cardiol 2024 Jan 16; 83:300. PMID: 38199707 https://www.sciencedirect.com/science/article/abs/pii/S0735109723080221