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carcinoembryonic antigen-related cell adhesion molecule 16; carcinoembryonic antigen-like 2 (CEACAM16, CEAL2)
Function:
- may play a role in maintaining integrity of the tectorial membrane
- monomer, homodimer, tetramer
- interacts with TECTA
Structure:
- belongs to the immunoglobulin superfamily, CEA family
- contains 2 Ig-like C2-type domain (immunoglobulin-like)
Compartment:
- secreted
- localizes to the tip of cochlear outer hair cells & to the tectorial membrane
Pathology:
- defects in CEACAM16 are the cause of deafness autosomal dominant type 4B
General
glycoprotein
human longevity protein
membrane protein
Properties
SIZE: entity length = 484 aa
MW = 53 kD
COMPARTMENT: cellular membrane
MOTIF: signal sequence {1-23}
N-glycosylation site {N95}
immunoglobulin superfamily domain {192-277}
MOTIF: cysteine residue {C212}
MODIFICATION: cysteine residue {C260}
cysteine residue {C260}
MODIFICATION: cysteine residue {C212}
immunoglobulin superfamily domain {282-368}
MOTIF: cysteine residue {C311}
MODIFICATION: cysteine residue {C352}
cysteine residue {C352}
MODIFICATION: cysteine residue {C311}
transmembrane domain {363-383}
Database Correlations
UniProt Q2WEN9
PFAM correlations
References
- UniProt :accession Q2WEN9
- PMID: 21368133
- PMID: 1368133
- PMID: 25589040