carboxypeptidase N catalytic chain (CPN, carboxypeptidase N polypeptide 1, carboxypeptidase N small subunit, Lysine carboxypeptidase, arginine carboxypeptidase, kininase-1, serum carboxypeptidase N, SCPN, anaphylatoxin inactivator, plasma carboxypeptidase B, CPN1, ACBP)

Function: - catalytic subunit of carboxypeptidase N - protective against potent vasoactive & inflammatory peptides containing C-terminal Arg or Lys (kinins or anaphylatoxins) which are released into the circulation Cofactor: binds 1 Zn⁺² per subunit (putative) Structure: belongs to the peptidase M14 family Compartment: secreted, extracellular space Expression: plasma

General

metalloprotein protein subunit

Properties

SIZE: entity length = 458 aa MW = 52 kD MOTIF: signal sequence {1-20} Zn+2-binding site SITE: 86-86 Zn+2-binding site SITE: 89-89 Zn+2-binding site SITE: 216-216 glutamate residue {E308}

Database Correlations

OMIM correlations MORBIDMAP 603103 UniProt P15169 Pfam PF00246 Entrez Gene 1369 Kegg hsa:1369 ENZYME 3.4.17.3

References

UniProt :accession P15169