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carboxypeptidase-N, plasma carboxypeptidase-B, kininase-1, anaphylatoxin inactivator or arginine carboxypeptidase
Function:
- protective against potent vasoactive & inflammatory peptides containing C-terminal Arg or Lys (kinins or anaphylatoxins) which are released into the circulation
Cofactor: binds 1 Zn+2 per subunit (putative)
Structure:
- tetramer of two catalytic chains & two glycosylated inactive chains
Compartment: secreted, extracellular space
Expression: plasma
General
carboxypeptidase
metalloprotease
multisubunit protein
secreted protein
Properties
COMPARTMENT: extracellular compartment
MOTIF: active site
metal ion-binding site
SUBUNITS: carboxypeptidase N catalytic chain (2)
MOTIF: signal sequence {1-20}
Zn+2-binding site
SITE: 86-86
Zn+2-binding site
SITE: 89-89
Zn+2-binding site
SITE: 216-216
glutamate residue {E308}
carboxypeptidase N subunit 2 (2)
MOTIF: signal sequence {1-21}
leucine-rich repeat
SITE: 72-95
MOTIF: leucine residue (SEVERAL)
N-glycosylation site {N74}
leucine-rich repeat
SITE: 96-119
MOTIF: leucine residue (SEVERAL)
N-glycosylation site {N111}
N-glycosylation site {N119}
leucine-rich repeat
SITE: 120-143
MOTIF: leucine residue (SEVERAL)
leucine-rich repeat
SITE: 144-167
MOTIF: leucine residue (SEVERAL)
leucine-rich repeat
SITE: 169-191
MOTIF: leucine residue (SEVERAL)
leucine-rich repeat
SITE: 192-215
MOTIF: leucine residue (SEVERAL)
leucine-rich repeat
SITE: 217-239
MOTIF: leucine residue (SEVERAL)
N-glycosylation site {N228}
leucine-rich repeat
SITE: 241-263
MOTIF: leucine residue (SEVERAL)
leucine-rich repeat
SITE: 264-287
MOTIF: leucine residue (SEVERAL)
N-glycosylation site {N266}
leucine-rich repeat
SITE: 289-311
MOTIF: leucine residue (SEVERAL)
leucine-rich repeat
SITE: 312-335
MOTIF: leucine residue (SEVERAL)
leucine-rich repeat
SITE: 337-359
MOTIF: leucine residue (SEVERAL)
N-glycosylation site {N348}
N-glycosylation site {N359}
leucine-rich repeat
SITE: 360-383
MOTIF: leucine residue (SEVERAL)
N-glycosylation site {N518}
Database Correlations
OMIM 212070
ENZYME 3.4.17.3
References
UniProt :accession P15169
Components
carboxypeptidase N catalytic chain (CPN, carboxypeptidase N polypeptide 1, carboxypeptidase N small subunit, Lysine carboxypeptidase, arginine carboxypeptidase, kininase-1, serum carboxypeptidase N, SCPN, anaphylatoxin inactivator, plasma carboxypeptidase B, CPN1, ACBP)
carboxypeptidase N subunit 2 (carboxypeptidase N polypeptide 2, carboxypeptidase N 83 kD chain, carboxypeptidase N regulatory subunit, carboxypeptidase N large subunit, CPN2, ACBP)