Search
carboxypeptidase-E (carboxypeptidase-H, prohormone-processing carboxypeptidase, enkephalin convertase, CPH, CPE)
Function:
- removes residual C-terminal Arg or Lys remaining after initial endoprotease cleavage during prohormone processing
- processes proinsulin
Cofactor: binds 1 Zn+2 per subunit (putative)
Structure: belongs to the peptidase M14 family
Compartment:
- secreted
- secretory granules of pancreatic islets, adrenal gland, pituitary & brain
Interactions
molecular events
General
carboxypeptidase
glycoprotein
metalloprotein
secreted protein
Properties
SIZE: entity length = 476 aa
MW = 53 kD
COMPARTMENT: extracellular compartment
MOTIF: signal sequence {1-25}
Zn+2-binding site
SITE: 114-114
Zn+2-binding site
SITE: 117-117
N-glycosylation site {N139}
Zn+2-binding site
SITE: 248-248
glutamate residue {E342}
N-glycosylation site {N390}
STATE: active state
Database Correlations
OMIM 114855
UniProt P16870
Pfam PF00246
Entrez Gene 1363
Kegg hsa:1363
ENZYME 3.4.17.10
References
- UniProt :accession P16870
- Weber SJ, Louis RB, Trombley L, Bissette G, Davies P, Davis TP.
Metabolic half-life of somatostatin and peptidase activities
are altered in Alzheimer's disease.
J Gerontol. 1992 Jan;47(1):B18-25.
PMID: 1346149